Bladder Cancer | Current Treatment: Physician Insights | US | 2022

Since the approval of immune checkpoint inhibitors, the treatment of bladder cancer has been transformed. Keytruda (Merck & Co.) and Opdivo (Bristol Myers Squibb) are now options in earlier settings, and Merck KGaA / Pfizer’s Bavencio will continue to be used in the first-line maintenance setting. The approval of novel drug classes for locally advanced unresectable or metastatic disease, such as Janssen’s first-in-class FGFR inhibitor Balversa (erdafitinib) for patients harboring susceptible FGFR2 or FGFR3 genetic alterations, and of antibody-drug conjugates (ADCs), such as Astellas / Seagen’s Padcev
(enfortumab vedotin-ejfv) and Gilead Sciences’ Trodelvy (sacituzumab govitecan), are further expanding physicians’ armamentarium and reshaping the treatment of bladder cancer.

Questions answered

• What percentage of high-risk non-muscle-invasive bladder cancer patients unresponsive to BCG receive Keytruda, and what is the treatment duration?
•  How do drug-treatment rates vary across key patient populations and treatment lines?
• What is the uptake of immune checkpoint inhibitors in the United States across therapy lines? How are immune checkpoint inhibitors faring against older (e.g., platinum-based chemotherapy) and newer therapies (e.g.,Balversa, Padcev, Trodelvy)?
• What clinical factors drive the use of Bavencio as a first-line maintenance therapy for unresectable locally advanced or metastatic disease?
• What are the main drivers of and obstacles to treatment with key drugs for unresectable locally advanced or metastatic bladder cancer?

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