Parkinson’s Disease | Current Treatment: Physician Insights | US | 2023

The treatment of Parkinson’s disease (PD) requires personalized care, a high degree of polypharmacy, and frequent adjustments to achieve symptom control throughout the disease course. Consequently, treatment paradigms in PD have become increasingly complex as the growing availability and uptake of new brands have bolstered disease management with an array of mechanistically distinct drug classes. In addition to the SOC levodopa and generically available mainstays in entrenched drug classes, physicians prescribe branded agents that target niche PD subpopulations with high unmet need (e.g., Sunovion’s Kynmobi, Supernus’s Gocovri, Acadia’s Nuplazid). With the PD therapy market poised to grow meaningfully—thanks to a dynamic pipeline of unique therapies designed to optimize and lengthen the benefits of levodopa, reduce the severity of levodopa-induced dyskinesia, and reduce the frequency and impact of motor response complications—understanding neurologists’ prescribing practices and decision points when treating PD is crucial for developers facing a competitive and evolving market.

Questions answered

• What percentage of PD patients suffer from motor response complications and nonmotor comorbidities? What treatments do neurologists favor for these subpopulations?
• What percentage of PD patients suffering from levodopa-induced dyskinesia receive drug therapy and with which drugs?
• How frequently are branded agents from drug classes with generically available options prescribed for PD?
• How and why has neurologists’ prescribing changed in the past year?
• What factors influence neurologists’ treatment practices for their PD patients at each stage of disease?

Product description

Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that marketers can create specific messaging around these treatment dynamics to more effectively increase or defend their market position.

Markets covered: United States

Key companies: AbbVie, Acadia, Acorda, Amneal, Kyowa Kirin, Lundbeck, Neurocrine, Sunovion, Supernus

Key drugs: Duopa, Gocovri, Inbrija, Kynmobi, Neupro, Northera, Nourianz, Nuplazid, Ongentys, Rytary, Xadago, all generic mainstays

Primary research: Survey of 101 U.S. neurologists

Key insights provided

• Factors influencing disease management and treatment decisions
• Drivers and constraints of treatment selection
• Physician-reported treatment practices and brand-level patient shares
• Rationale for changes in treatment approach
• Physician insight on persistency and compliance
• Physician-reported recent / anticipated changes in brand usage or treatment approach