Gout | Treatment Algorithms: Claims Data Analysis | US | 2025

Gout, a form of inflammatory arthritis, arises due to the persistent elevation of serum uric acid (sUA) levels. The condition manifests through sudden and intense gout flares, causing significant discomfort. (The treatment of acute flares is distinct from that of chronic gout and is not the focus of this analysis.) Chronic treatment aims to avert recurrent gout attacks and prevent joint damage by reducing sUA levels. Xanthine oxidase inhibitors (XOIs), especially the widely prescribed generic allopurinol, form the cornerstone of chronic gout treatment. For later lines of therapy, Krystexxa, a highly efficacious biological drug, is used. This report offers valuable insight into the application of these treatments in patients newly diagnosed with or recently treated for chronic gout.

Questions answered

• What patient shares do key therapies and brands garner by line of therapy in newly diagnosed gout patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed gout patients?
• How has Krystexxa been integrated into the treatment algorithm, and what is its source of business?
• What percentage of gout patients receive drug therapy within 365 days of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within 365 days of diagnosis?
• What percentage of gout patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
• What are the product-level compliance and persistency rates among drug-treated patients?

Markets covered: United States

Key drugs: Allopurinol, Febuxostat, Krystexxa, Probenecid

Product description

Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data, enabling you to:

• Understand patient flow between lines of therapy.
• Evaluate your brand share against competitors.
• Accurately assess your source of business.
• Quantify opportunities at different stages of the treatment algorithm

Produce enhancement

Treatment Algorithms: Claims Data Analysis leverages Clarivate’s proprietary Real-World Data, which brings larger patient samples, broader payer coverage, and faster availability for more robust and timely analyses. Additionally, we include new patient demographic analyses: age, gender, ethnicity, and region.