Product logins

Find logins to all Clarivate products below.

home   •  Research Reports  •  DRG Market Assessment Reports

Systemic Lupus Erythematosus | Unmet Need | US/EU | 2020

Login to access report north_east
Contact sales account_box

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect different organ systems of the body and manifest in a wide range of clinical symptoms, from general fatigue to serious renal and CNS manifestations. Most drugs used to treat SLE are older, generically available, and off-label. To date, GlaxoSmithKline’s Benlysta—viewed by many physicians as only modestly effective—is the only drug approved for moderate to severe SLE (excluding severe active renal and severe active CNS manifestations). Thus, unmet need remains high in the moderate to severe subpopulation, leaving significant commercial opportunity for novel SLE therapies offering a better efficacy profile than that of Benlysta.

QUESTIONS ANSWERED

  • What are the treatment drivers and goals in moderate to severe SLE (excluding severe active renal and severe active CNS manifestations)?
  • What drug attributes are key influencers, which have limited impact, and which are hidden opportunities?
  • How do current therapies perform on key treatment drivers and goals for moderate to severe SLE (excluding severe active renal and severe active CNS manifestations)?
  • What are the prevailing areas of unmet need and opportunity in the treatment of moderate to severe SLE (excluding severe active renal and severe active CNS manifestations)?
  • What trade-offs across different clinical attributes and price are acceptable to rheumatologists for a hypothetical new drug for moderate to severe SLE (excluding severe active renal and severe active CNS manifestations)?

PRODUCT DESCRIPTION

Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.

Markets covered: United States, United Kingdom, France, Germany

Primary research: Survey of 61 U.S. and 30 European rheumatologists fielded in December 2019

Key companies: GlaxoSmithKline, Bristol-Myers Squibb, Roche, AstraZeneca, Janssen, Eli Lilly

Key drugs: Benlysta, Rituxan / MabThera, CellCept, hydroxychloroquine, methotrexate, azathioprine

Contact sales account_box
Login to access report north_east

Related Market Assessment Reports

Report
Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia – Current Treatment – Current Treatment: Physician Insights – B-Cell Non-Hodgkin’s Lymphoma (US)
Non-Hodgkin’s lymphoma (NHL) represents a diverse group of hematological malignancies broadly classified into indolent and aggressive subtypes. Patients with aggressive NHL—diffuse large B-cell…
north_east
Report
Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia – Current Treatment – Treatment Sequencing – B-Cell Non-Hodgkin’s Lymphoma (US)
Key benefits and usesPinpoint current drug positioning and uptake in one snapshot to facilitate forecasting.Drill down into physicians’ treatment sequences and understand who to position against…
north_east
Report
Non-Small-Cell Lung Cancer – Unmet Need – Unmet Need – Metastatic NSCLC without driver mutations (US EU)
First-line treatment for non-small-cell lung cancer (NSCLC) patients without driver mutations typically includes an immune checkpoint inhibitor, with or without platinum-based chemotherapy,…
north_east
Report
Psoriasis – Unmet Need – Unmet Need – Moderate to Severe Psoriasis (US/EU)
Topical therapies are the backbone of psoriasis management; however, they are often inadequate for patients with moderate to severe disease, who typically require systemic treatment. While…
north_east
Report
Eosinophilic Esophagitis – Unmet Need – Unmet Need – Eosinophilic Esophagitis (US/EU)
Standard treatments for eosinophilic esophagitis (EoE) typically include proton pump inhibitors (PPIs) and swallowed topical steroids. Although these therapies can alleviate EoE symptoms, their…
north_east

Follow us

Contact us

Sales enquiries north_east
Customer service north_east
Support north_east