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Bullous Pemphigoid – Executive Insights – Bullous Pemphigoid | Executive Insights | US/EU5 | 2022

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Bullous pemphigoid (BP) is the most common type of subepidermal autoimmune bullous diseases, which characteristically affects the elderly and is seen mainly in patients older than 60. The disease is often misdiagnosed, and it takes an average of five visits to healthcare providers and approximately six months to obtain a correct diagnosis. No therapies are approved for BP in the United States. The corticosteroid prednisolone is authorized in some EU countries. In general, symptoms and disease progression are controlled by off-label corticosteroids (topical, systemic) in combination with immunomodulators / immunosuppressants, high-dose IVIG, and rituximab. The BP pipeline is crowded, with three molecules in advanced phases of clinical development (Phase III): AstraZeneca’s Fasenra SC (anti-IL-5), Sanofi / Regeneron’s Dupixent (anti-IL-4/IL-13), and Akari Therapeutics’ nomacopan (C5a + leukotriene B4 inhibitor). Three additional drugs are in Phase II development. Given the lack of approved therapies, unavailability of diagnostic biomarkers, and vulnerability of the patient population, the unmet needs and market opportunities for new therapies for BP are clear.

Questions answered

  • What is the diagnosed incidence of BP, and how are patients currently treated in the different markets under study?
  • What are the key unmet needs and areas of opportunity in the management of BP?
  • What is the potential impact of pipeline therapies and how will these therapies affect future market dynamics in BP?
  • What are the key drivers and limiters of the BP market?
  • What are the challenges associated with the market access and reimbursement of new therapies in BP?

Product description

Executive Insights provides indication-specific market intelligence with world-class epidemiology, keen insight into current treatment paradigms, biotherapeutic pipelines, key clinical unmet needs, and competitive landscapes, supported by primary and secondary research. This solution provides succinct insights to any biopharma function or business professional looking to quickly grasp a new indication of interest.

Geography: United States, EU5

Primary research: 13 KOL interviews from November 2021 to January 2022

Key companies covered: AstraZeneca, Akari Therapeutics, Sanofi / Regeneron, Argenx, Alkahest, Innate Pharma

Key drugs covered: Fasenra, nomacopan, Dupixent, efgartigimod, AKST4290, avdoralimab

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