Ischemic Stroke | Executive Insights | US | 2020
Ischemic stroke (IS) is one of the leading causes of death and neurological disability worldwide. Despite the significant burden of IS, recombinant tissue plasminogen activator (rt-PA/alteplase [Genentech’s Activase, other brands]) is the only pharmacological therapy approved for the (acute) treatment of IS owing to persistent failure of investigational compounds over the past two decades. However, because of strict inclusion criteria and documented safety risks, only a small fraction of diagnosed IS events receive rt-PA. Therefore, a tremendous amount of unmet clinical need remains for alternative treatments that can help avert permanent neurological damage and restore neurological function in post-stroke survivors living with residual impairment.
QUESTIONS ANSWERED
- What percentage of IS patients arrive at the hospital within key time windows for acute drug and/or device intervention?
- How is IS currently managed? What drugs, diagnostics, and devices are used to treat IS, and what are their advantages and disadvantages?
- What are the key areas of unmet need and opportunity in IS? What are the key drivers and limiters of the therapy market?
- What promising agents are advancing through the IS pipeline? How might treatment change with the introduction of novel products? What companies are most vested in developing innovative therapies for IS?
- What is the clinical and commercial potential of late-phase pipeline products in development for the acute and post-acute phase treatment of IS, and what will be their likely positioning should they come to market?
CONTENT HIGHLIGHTS
Geography: United States
Primary Research: 3 KOL interviews in April 2020
Key Companies Covered: Genentech / Roche, Boehringer Ingelheim, Mitsubishi Tanabe Pharma, Biogen, Genervon, Athersys, ZZ Biotech, SanBio, Lumosa Therapeutics, ReNeuron, Stemedica Cell Technologies, NoNO
Key Drugs Covered: rt-PA/alteplase (Activase/Actilyse, other brands), edaravone (Radicut, generics), citicoline (Somazina, generics), tenecteplase, glibenclamide, 3K3A-APC, GM602, MultiStem, SB 623, LT 3001, ReN-001, NA-1
PRODUCT DESCRIPTION
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