Axial Spondyloarthritis | Disease Landscape & Forecast | G7
The axial spondyloarthritis (AxSpA) therapy market includes biologics from two distinct drug classes: tumor necrosis factor-alpha (TNF-α) inhibitors (Amgen / Pfizer’s Enbrel, AbbVie’s Humira, Janssen’s Remicade and Simponi / Simponi Aria, and UCB’s Cimzia); and IL-17 inhibitors (Novartis’s Cosentyx and Eli Lilly’s Taltz). The TNF-α inhibitors are the most widely prescribed biologics for AxSpA that is refractory to nonsteroidal anti-inflammatory drugs (NSAIDs). However, these agents face a competitive threat, both from the launch of cost-effective biosimilars and from the growing IL-17 class. In 2019, the FDA approved Cimzia for nonradiographic (nr)-AxSpA, marking the first FDA approval for this subpopulation. The FDA approved both IL-17 inhibitors in June 2020 and Rinvoq in October 2022. The recent approval of additional IL-17 inhibitor, (UCB’s Bimzelx) and Cosentyx’s IV formulation—for ankylosing spondylitis (AS) and nonradiographic (nr)-AxSpA—will intensify the competition, leading to a shift in the AxSpA treatment landscape.
Questions answered:
- How large is the treatable AxSpA population, and how will diagnosis / drug-treatment rates change over time?
- What are interviewed experts’ insights on current treatment options for AS and nr-AxSpA? What clinical needs remain unfulfilled?
- What pipeline products are the most promising, and what key therapies are in early-phase development?
- What are interviewed experts’ opinions of the use of Xeljanz and Rinvoq for AS? What sales / uptake could JAK inhibitors secure in AxSpA?
- What are the drivers of and constraints in the AxSpA therapy market, and how will the market evolve over the forecast period?
Content highlights:
Geographies: United States, EU5, Japan
Primary research: 31 country-specific interviews with thought-leading rheumatologists; supported by survey data collected for this and other Clarivate research.
Epidemiology: Diagnosed prevalent cases of AxSpA by country; AS and nr-AxSpA subpopulations.
Forecast: 10-year, annualized, drug-level sales and patient share of key AxSpA therapies through 2032, segmented by brands / generics and epidemiological subpopulations
Emerging therapies: Phase 3: 1 drug; Phase 2: 2 drugs
Product description:
Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
Solution enhancement
Disease Landscape & Forecast will be updated throughout the year to provide timely insights and analyses as material indication-specific news and events unfold.
Disease Landscape & Forecast features a Drug Pipeline chapter with real-time, global pipeline intelligence content directly from Cortellis. This chapter is updated daily and features interactive figures that can be easily downloaded for detailed analysis or presentations.
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