Regulatory compliance of controlled substances and suspicious order monitoring: A comparative analysis

The regulation of Controlled Substances (CS) and the implementation of Suspicious Order Monitoring (SOM) systems have become critical facets of modern public health and law enforcement policy across the globe. With rising concerns around opioid epidemics, illicit trafficking of psychotropic drugs, and the growing prevalence of novel psychoactive substances (NPS), regulatory authorities are under pressure to develop robust, transparent, and interoperable mechanisms for managing drug supply chains.
This article explores the global landscape of controlled substance and suspicious order monitoring regulation, with a focus on recent legislative updates, national monitoring systems, and collaborative frameworks for mitigating their misuse. CS and SOM regulations from selected countries across Europe, Middle East and Africa, Asia Pacific, North America and Latin America are analysed, revealing the evolution of regulatory policies, patterns in enforcement mechanisms, and inter-regional cooperation models for controlled substances and suspicious order monitoring.
The research delves into legislative updates, collaborative frameworks, and enforcement mechanisms used to counter drug misuse, and emphasizes regional collaboration and digital tracking systems. This article aims to guide stakeholders in policy alignment, risk mitigation, and operational harmonization within the global controlled substances supply chain, including visual charts and tables to support the comparative analysis.