Heart Failure | Preserved Ejection Fraction | Treatment Algorithms: Claims Data Analysis | US | 2024

Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all chronic heart failure cases, and even though understanding of the disease’s pathophysiology has improved, pharmacological treatments with proven outcomes and benefits in HFpEF have been elusive. Drug treatments still focus on managing comorbidities, and first-line treatment typically consists of RAAS inhibitors, beta blockers, and diuretics. Also, unlike in heart failure patients with reduced ejection fraction (HFrEF), calcium channel blockers can be used in this subpopulation. The treatments for HFpEF are limited, but with the emergence of Entresto, Jardiance, and Farxiga, the SOCs for HFpEF patients are evolving rapidly. This analysis provides insight into U.S. prescribing patterns for HFpEF.

Questions answered

• What patient shares do key therapies and brands garner by line of therapy in newly diagnosed HFpEF patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed HFpEF patients?
• How have Entresto and Farxiga been integrated into the treatment algorithm, and what are their source of business?
• What percentage of HFpEF patients receive drug therapy within one year of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within one year of diagnosis?
• What percentage of HFpEF patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
• What are the product-level compliance and persistency rates among drug-treated patients?

Markets covered: United States

Key companies: Pfizer, Merck & Co., Novartis, GSK, AstraZeneca, Johnson & Johnson, Eli Lilly, Boehringer Ingelheim, Amgen

Key drugs: ACE inhibitors, ARBs, beta blockers, diuretics, aldosterone antagonists, nitrates, BiDil, Corlanor, Entresto

Product description

Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.

Key feature

Dashboard featuring interactive visuals, easy navigation, and expanded analyses