9月25日，科睿唯安公佈了2025年度引文桂冠獎名單，美國德州大學西南醫學中心生物物理系傑出講席教授 Michael K. Rosen、美國普林斯頓大學 Omenn- Darling 生物工程研究所所長、工程學教授、化學與生物工程學教授 Clifford P. Brangwynne 與德國馬克斯·普朗克分子細胞生物學與遺傳學研究所所長 Anthony A. Hyman，因在「發現相分離生物分子凝聚體在細胞生化組織中的作用」研究領域的突出貢獻，共同獲得2025年度化學領域引文桂冠獎。
Michael Rosen 教授/圖源：Citation Laureates 官網
Michael Rosen 博士畢業於哈佛大學化學系，導師為 Stuart L. Schreiber教授（哈佛大學化學與化學生物學系教授，美國國家科學院院士，沃爾夫化學獎獲得者）。其博士論文題目為：The molecular basis of receptor-ligand-receptor interactions: Studies of the immunophilin FKBP12。該論文全文收錄在ProQuest全球博碩士論文資料庫（ProQuest Dissertations & Theses Global，簡稱PQDT Global） 中。以下是論文的相關資訊，讀者可點擊連結查閱論文。
摘要
Signal transduction is responsible for the regulation of fundamental aspects of cell function. In many systems, signaling occurs through the formation of large, multimolecular assemblies. Analyses of the molecular recognition involved in complex formation will thus provide an understanding of signaling processes at the atomic level. The research described in this thesis is focused on the structural basis of the inhibition of the protein phosphatase, calcineurin, by the complex the immunophilin FKBP12 and the natural product FK506. Inhibition occurs through formation of a pentamolecular complex. Chapter 2 describes NMR analyses of FKBP12 to determine the $\sp1$H and $\sp{15}$N chemical shift assignments and secondary structure of the protein. FKBP12 was found to contain a 5-stranded antiparallel $\beta$-sheet with a novel folding topology involving a crossing of two strand-connecting loops. In chapter 3, the structure determination of FKBP12 at low and high resolution is presented. The loop-crossing region is found to be stabilized by extensive van der Waals and hydrogen bonding interactions. Differences in structure and dynamics between the free protein and the FKBP12-ligand complexes occur predominantly in the 40s and 80s loops, which surround the ligand-binding site. Finally, chapter 4 describes the use of structure-based site directed mutagenesis to determine the regions of the composite FKBP12-FK506 surface that interact with calcineurin. Critical contact residues are found in both the 40s and 80s loops. The data are discussed in light of the recently-determined structure of the FKBP13-FK506 complex.
論文連結：
https://www.proquest.com/pqdtglobal/docview/304086163
ProQuest Dissertations & Theses Global 簡介
ProQuest 是美國國會圖書館指定的收藏全美國博碩士論文的機構。 ProQuest 全球博碩士論文全文資料庫（ProQuest Dissertations & Theses Global，簡稱 PQDT Global），收錄來自全球60多個國家/地區4100餘所大學的超過400萬篇博碩士學位論文全文及600萬篇文摘索引記錄。 內容覆蓋科學、工程學、經濟與管理科學、健康與醫學、歷史學、人文及社會科學等領域。
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