Myelodysplastic Syndromes – Landscape & Forecast – Niche & Rare Disease Landscape & Forecast
Myelodysplastic syndromes (MDS) are a heterogeneous collection of hematopoietic stem cell disorders, which result in cytopenia and an increased risk of progression to acute myeloid leukemia (AML). BMS / Acceleron’s Reblozyl (luspatercept) for lower-risk adult MDS, Astex Pharmaceuticals’ Inqovi (decitabine and cedazuridine) for higher-risk adult MDS and refractory MDS, Servier’s Tibsovo (ivosidenib) for relapsed or refractory MDS with an IDH1 mutation, and Geron’s Rytelo (imetelstat) for low- to intermediate-1-risk adult MDS are effective treatment options. Other pharmacological approaches to managing the disease (e.g., lenalidomide [BMS’s Revlimid, generics]) are designed to ameliorate symptoms and extend patients’ survival, although there is a significant gap in the treatment of refractory disease. The MDS pipeline is robust and promising, and several projected market entrants are poised to penetrate the lower-risk, intermediate-risk, and higher-risk subpopulations.
Questions answered
- How have the U.S. launches of Reblozyl, Inqovi, Tibsovo, and Rytelo changed MDS treatment in that country? How will the treatment of MDS in Europe change following the expected EMA label expansions of Tibsovo and launch of Rytelo?
- What is the commercial outlook for current and emerging therapies for MDS?
- Which emerging therapies are most likely to have an impact on the MDS therapy market by 2034?
- How will the size of the MDS population change by 2034?
Geography: United States and EU5
Primary research:
- Country-specific interviews with thought-leading hematologists / oncologists
- Survey data collected for this and other Clarivate research
Epidemiology: Diagnosed incident and diagnosed prevalent cases of MDS by country, diagnosed and drug-treated incident cases of MDS, diagnosed incident and prevalent cases of MDS by morphology, and diagnosed incident and prevalent cases by prognostic risk
Forecast: Drug-level sales and patient share of key MDS therapies in 2024 and 2034
Drug treatments: Coverage of key current and late-phase emerging therapies
Product description
Niche & Rare Disease Landscape & Forecast offers comprehensive market intelligence with world-class epidemiology, keen insight into current and emerging therapies, and drug forecasts supported by detailed primary and secondary research, enabling you to:
- Optimize your long-term disease and development strategy.
- Quantify market potential for your pipeline assets and those of your competitors.
- Understand a disease from top to bottom, including key patient populations, the current and future therapeutic landscape, and the evolving market trajectory.
- Gauge the commercial outlook and impact of key market events.
Table of contents
- Myelodysplastic Syndromes - Landscape & Forecast - Niche & Rare Disease Landscape & Forecast
- Executive Summary
- Commercial Outlook and Forecast
- Key takeaways
- Market drivers and constraints
- Drug-class-specific trends
- Forecast
- Sales of key therapies in myelodysplastic syndromes: 2024 and 2034
- Patient shares of key therapies in lower-risk myelodysplastic syndromes: 2024 and 2034
- Patient shares of key therapies in intermediate-risk myelodysplastic syndromes: 2024 and 2034
- Patient shares of key therapies in higher-risk myelodysplastic syndromes: 2024 and 2034
- Key takeaways
- Disease Context
- About myelodysplastic syndromes
- Diagnosis of myelodysplastic syndromes
- Classification systems for myelodysplastic syndromes
- Pathologic-morphological classification of myelodysplastic neoplasms 2023
- Pathologic-morphological classification of myelodysplastic neoplasms 2023
- Prognostic scoring system for myelodysplastic syndromes
- Revised international prognostic scoring system for myelodysplastic syndromes
- WHO-based prognostic scoring system for myelodysplastic syndromes
- Molecular international prognostic scoring system for myelodysplastic syndromes
- Molecular mutations found in myelodysplastic syndromes
- Epidemiology
- Key takeaways
- Diagnosed incident cases of myelodysplastic syndromes
- Diagnosed prevalent cases of myelodysplastic syndromes
- Morphological subtypes of myelodysplastic syndromes
- IPSS and IPSS-R score
- Disease definition, methods, and sources used
- Diagnosed incident cases of myelodysplastic syndromes by IPSS risk: 2024-2034
- Diagnosed incident cases of myelodysplastic syndromes by IPSS-R risk: 2024-2034
- Diagnosed prevalent cases of myelodysplastic syndromes by IPSS risk: 2024-2034
- Diagnosed prevalent cases of myelodysplastic syndromes by IPSS-R risk: 2024-2034
- Diagnosed and drug-treated populations
- Key takeaways
- Current Treatment
- Emerging Therapies
- Drug Pipeline
- Methodology
- Bottom-up forecasting overview
- Bottom-up forecast key events and assumptions
- Market events impacting the myelodysplastic syndromes forecast
- Drug-treatment rate assumptions in myelodysplastic syndromes
- Forecast market authorization and launch dates of key emerging therapies for the treatment of myelodysplastic syndromes
- Generic erosion
- Generic erosion assumptions
- Dosing, days of therapy, and compliance assumptions of key therapies in lower-risk myelodysplastic syndromes
- Dosing, days of therapy, and compliance assumptions of key therapies in intermediate-risk myelodysplastic syndromes
- Dosing, days of therapy, and compliance assumptions of key therapies in higher-risk myelodysplastic syndromes
- Dosing, days of therapy, and compliance assumptions of key therapies in any-risk myelodysplastic syndromes
- Emerging therapy prices
- Prices of key current and emerging therapies used to treat myelodysplastic syndromes
- Bottom-up forecast methodology
- Primary market research
- Appendix
- Executive Summary