優秀博士論文 | 2023年北美研究生院理事會/ProQuest 優秀博士學位論文獎 - Clarivate

本文分享2篇北美高校的優秀博士論文，這兩篇論文獲2023年北美研究生院理事會/ProQuest 優秀博士學位論文獎。該獎項是北美研究生院理事會（The Council of Graduate Schools，CGS ）與 ProQuest（現隸屬於科睿唯安）於1982年設立的專案，為表彰CGS 高校培養的博士生所取得的具有重要意義、創新性強的博士學位論文，以推動青年學者在相關領域的學術創新。

人文社科

Stories from Inside the Circle: Embodied Indigeneity and Resurgent Practice in Post-Secondary Institutions

作者：Cunningham, Shawna M.

導師：Field, James C.

答辯委員會委員：Committee member: Pidgeon, Michelle E.; Hanson, Aubrey J.; Waterman, Stephanie J.

學位授予機構：University of Calgary (Canada)

學科分類：0741: Indigenous studies; 0745: Higher education; 0393: Epistemology

摘要：

The call for reconciliation through education (Truth and Reconciliation Commission of Canada, 2015a) has compelled public post-secondary institutions in Canada to engage in meaningful and sustainable acts of reconciliation through systemic transformation. While the Final Report of the Truth and Reconciliation Commission of Canada (2015a) has brought to the forefront the urgency for reconciliation, individual and collective acts of decolonization and indigenization have been unfolding in the small corners and shadows of public post-secondary institutions in Canada since the early 1970s (Pidgeon et al., 2014; Pidgeon, 2014). For decades,Indigenous student service centres have had a visible presence in public post-secondary institutions across Canada, symbolizing a cultural touchstone for Indigenous students and serving as long-standing beacons of welcome for Indigenous community members. Indigenous leaders and associated staff of the centres have been actively engaged in the decolonization and indigenization of public post-secondary institutions in Canada as a distinct community of practice, laying much of the initial groundwork for transformative reconciliation in higher education.

Through the storied experience of nine Indigenous leaders of the centre, this study offers insight into their role, experiences, and perspectives on decolonization and indigenization unfolding in public post-secondary institutions across Canada, now responsive to the call for reconciliation through education (Truth and Reconciliation Commission of Canada, 2015a). This research study is concerned with how Indigeneity as embodied presence (Meyer, 2008) gives rise to a cultural resurgent practice (Burrows & Tully, 2018; Simpson, 2017) in a neocolonial educational system poised for transformative reconciliation (Burrows & Tully, 2018). The study employs an Indigenous storytelling methodology (Kovach, 2009) reliant on the seven principles of storywork (Archibald, 2008) as an ethical framework for gathering stories, and Indigenousmétissage (Donald, 2012) as a thematic analytical framework for making meaning. The study is further informed by theoretical concepts of trans-systemic space, pedagogy, and practice (Battiste,2013; Battiste & Henderson, 2021, Henderson, 2009; Styres, 2017), the ethical space of engagement (Ermine, 2007) and ethical relationality (Donald, 2016).

論文連結：https://www.proquest.com/pqdtglobal/docview/2895736340

生物學與生命科學

Genotypic and Phenotypic Predictors of Cancer Therapy Adherence and Symptom Trajectories in Women with Breast Cancer

作者：McCall, Maura Kindelan

導師：Bender, Catherine M.

學位授予機構：University of Pittsburgh

學科分類：0992: Oncology; 0569: Nursing; 0573: Public health

摘要：

Aromatase inhibitors (AI) such as anastrozole effectively prevent hormone receptor positive breast cancer (HR+BC) recurrence but suboptimal AI adherence is a problem linked to AI-related, highly-variable symptoms, which may have biological underpinnings. This dissertation study is an ancillary study of prospectively-collected data from parent observational studies. This study combined parent study data from postmenopausal women prescribed anastrozole for HR+BC with symptom data (N=360), adherence data (N=291), and banked biospecimens (N=122). This study identified distinct subgroups using group-based trajectory modeling (GBTM) based on self-reported symptom and anastrozole adherence trajectories over the first 18-months of therapy (Aim 1), identified combined symptom and adherence trajectories (Aim 2); and explored whether genotypic and phenotypic factors (e.g., demographic, clinical) were associated with trajectory group membership (Aim 3). Using neuropsychological symptom data (N=360) collected at pre-anastrozole, 6-, 12-, and 18-months post-initiation, we found five distinct trajectories of neuropsychological symptom burden (NSB)—low-stable, low-increasing, moderate-stable, high-stable, and high-increasing (Aim 1). Anastrozole adherence data (N=291) collected via electronic event monitoring (MEMS®) were measured continuously for 18 months. We used monthly calculations for GBTM and found five trajectories: very low, low, high/sharp decrease, high/slow decrease, and persistently high (Aim 1). Most women were adherent; however, within five months, anastrozole adherence was at or below 80% in more than one-third of the sample. The relationship between NSB and adherence trajectories were examined simultaneously using a dual GBTM in 291 women (Aim 2). After NSB trajectories were re-evaluated for the 291 sample, a dual trajectory analysis suggested a bidirectional relationship between NSB and anastrozole adherence. However, for most women, taking anastrozole does not result in increased neuropsychological symptom burden. Phenotypic risk factors (Aim 3) to predict trajectories with greater NSB (N=360), included younger age and baseline (pre-anastrozole) medication use, including anti-depressants, non-narcotic analgesics, narcotic analgesics, anti-anxiety, and no calcium/vitamin D use. Protective factors for women in the higher (better) adherence trajectories (N=291) included not using thyroid medications or antidepressants. Younger age predicted greater NSB in the dual GBTM. Genotypic factors for greater NSB were PGR rs471767 and ESR1 rs1884051. Genotypic factors for greater adherence were ESR1 rs985694 and PGR rs1942836.

論文連結：https://www.proquest.com/pqdtglobal/docview/2823466363

參考文獻：

Winners of 2023 CGS/ProQuest Distinguished Dissertation Awards Announced https://cgsnet.org/press-releases/winners-of-2023-cgs-proquest-distinguished-dissertation-awards-announced

ProQuest Dissertations & Theses Global 簡介