Acute myeloid leukemia (AML) is the most common and aggressive form of leukemia in adults, with the lowest survival rates of all blood cancer types. Despite significant advances in understanding the disease, current treatment is dominated by chemotherapeutic agents offering limited efficacy benefits, after which recurrence is almost guaranteed. After years of dormancy and high levels of unmet need, four new drug approvals in 2017—Rydapt (Novartis), Idhifa (Celgene/Agios Pharmaceuticals), Mylotarg (Pfizer), and Vyxeos (Jazz Pharmaceuticals)—are expected to transform the way AML is treated. We assess how current therapies perform on key drug attributes and measure the impact of attributes on physicians’ prescribing behavior. We also consider which unmet needs novel therapies should address to distinguish themselves from their rivals and maximize uptake.
Unmet Need provides quantitative insight into U.S. and European physician perceptions of key treatment drivers and goals and the current level of unmet need for a specific disease. Commercial opportunities are analyzed, and the extent to which emerging therapies may capitalize on these opportunities is evaluated.
United States, France, Germany, United Kingdom
Survey of 60 hematologist-oncologists in U.S. and 30 hematologists in Europe
KEY DRUGS COVERED
Dacogen, gilteritinib, guadecitabine, Mylotarg, Venclexta/Venclyxto, Vidaza, quizartinib
KEY METRICS INCLUDED