Treatment of BRAF-mutation-positive unresectable or metastatic malignant melanoma has been transformed in recent years by the identification of BRAFmutations and the development of BRAF and MEK inhibitors, as well as by establishing the disease’s immunogenic properties and subsequent immunotherapy advances. Despite the remarkable OS and PFS data demonstrated by some of the new therapies, the prevailing unmet needs in the treatment of BRAF-mutation-positive unresectable or metastatic malignant melanoma focus on further improvements in OS and PFS against current therapies, which continue to be sought by physicians and regulatory authorities alike. Other key efficacy challenges are to overcome the relatively low ORR associated with immunotherapies and to overcome the relatively short DoR associated with BRAF and MEK inhibitors. Minimizing the incidence of treatment-related toxicities, particularly the incidence of immune-related AEs, is another important unmet need in BRAF-mutation-positive unresectable or metastatic malignant melanoma.
Markets covered: United States, United Kingdom, France, Germany
Primary research: Survey of 60 U.S. and 30 European medical oncologists fielded in January 2017.
Key companies: Bristol-Myers Squibb, Novartis, Merck
Key drugs: Opdivo, Yervoy, Tafinlar