Ovarian Cancer – Unmet Need – Detailed, Expanded Analysis: Advanced Platinum-Sensitive Ovarian Cancer (US/EU)
The treatment landscape of advanced platinum-sensitive ovarian cancer has been revolutionized by poly ADP ribose polymerase (PARP) inhibitors (AstraZeneca’s and Merck & Co.’s Lynparza, GSK’s Zejula, and Clovis Oncology’s Rubraca). With the approval of Lynparza and Zejula in the first-line maintenance setting, PARP inhibitors have become the new standard of care; however, these drugs provide the greatest benefit to patients with BRCA mutations or deficiencies in homologous recombination and have shown limited efficacy in patients without these genetic alterations. Availability of treatment options after disease progression is limited; the FDA’s enhanced scrutiny of PARP inhibitors led to withdrawals and label restrictions, creating further void. In addition, the optimal sequencing of therapies is not clear. A pressing unmet need remains for patients with advanced platinum-sensitive ovarian cancer.
QUESTIONS ANSWERED
- What are the key factors and goals driving medical oncologists’ prescribing decisions for advanced platinum-sensitive ovarian cancer?
- How do current therapies, such as Zejula and Lynparza, perform on key clinical attributes in this setting? Are medical oncologists satisfied with the available treatments?
- What are the most urgent unmet needs in advanced platinum-sensitive ovarian cancer? What are the most attractive opportunities for the development of novel therapies for this disease?
- What trade-offs are acceptable for U.S. and European physicians across key clinical attributes and price for a new drug for advanced platinum-sensitive ovarian cancer?
PRODUCT DESCRIPTION
Provides quantitative insight into U.S. and European physician perceptions of key treatment drivers and goals and the current level of unmet need for a specific disease. Commercial opportunities are analyzed, and the extent to which emerging therapies may capitalize on these opportunities is evaluated.
Markets covered: United States, United Kingdom, France, Germany
Primary research: Survey of 61 U.S. and 31 European medical oncologists fielded in February 2023.
Key companies: AstraZeneca, GSK, Clovis Oncology
Key drugs: Lynparza, Zejula, Rubraca, bevacizumab
Table of contents
- Ovarian Cancer - Unmet Need - Detailed, Expanded Analysis: Advanced Platinum-Sensitive Ovarian Cancer (US/EU)
- Executive summary
- Unmet Need - advanced platinum-sensitive ovarian cancer - executive summary - May 2023
- Introduction
- Overview
- Methodology
- Rationale for treatment drivers and goals selection
- Rationale for drug selection
- Regimens for platinum-sensitive ovarian cancer and rationale for drug selection
- Treatment drivers and goals
- Key findings: attribute importance
- Relative importance of efficacy, safety and tolerability, convenience of administration, and nonclinical attributes to surveyed medical oncologists' prescribing decisions in advanced platinum-sensitive ovarian cancer
- Importance of efficacy attributes to prescribing decisions in advanced platinum-sensitive ovarian cancer: United States
- Importance of efficacy attributes to prescribing decisions in advanced platinum-sensitive ovarian cancer: Europe
- Importance of safety and tolerability attributes to prescribing decisions in advanced platinum-sensitive ovarian cancer: United States
- Importance of safety and tolerability attributes to prescribing decisions in advanced platinum-sensitive ovarian cancer: Europe
- Importance of convenience of administration attributes to prescribing decisions in advanced platinum-sensitive ovarian cancer: United States
- Importance of convenience of administration attributes to prescribing decisions in advanced platinum-sensitive ovarian cancer: Europe
- Importance of nonclinical factors to prescribing decisions in advanced platinum-sensitive ovarian cancer: United States
- Importance of nonclinical factors to prescribing decisions in advanced platinum-sensitive ovarian cancer: Europe
- Key findings: stated vs. derived importance
- Stated vs. derived importance of key efficacy, safety and tolerability, convenience of administration, and nonclinical attributes to prescribing decisions in advanced platinum-sensitive ovarian cancer: United States
- Stated vs. derived importance of key efficacy, safety and tolerability, convenience of administration, and nonclinical attributes to prescribing decisions in advanced platinum-sensitive ovarian cancer: Europe
- Product performance against treatment drivers and goals
- Key findings
- Overall performance of key therapies for advanced platinum-sensitive ovarian cancer: United States
- Overall performance of key therapies for advanced platinum-sensitive ovarian cancer: Europe
- Mean overall performance of key therapies for advanced platinum-sensitive ovarian cancer: United States and Europe
- Relative performance of key therapies for advanced platinum-sensitive ovarian cancer across select efficacy attributes: United States
- Relative performance of key therapies for advanced platinum-sensitive ovarian cancer across select efficacy attributes: Europe
- Relative performance of key therapies for advanced platinum-sensitive ovarian cancer across select safety and tolerability attributes: United States
- Relative performance of key therapies for advanced platinum-sensitive ovarian cancer across select safety and tolerability attributes: Europe
- Relative performance of key therapies for advanced platinum-sensitive ovarian cancer across select convenience of administration attributes: United States
- Relative performance of key therapies for advanced platinum-sensitive ovarian cancer across select convenience of administration attributes: Europe
- Relative performance of key therapies for advanced platinum-sensitive ovarian cancer across select nonclinical attributes: United States
- Relative performance of key therapies for advanced platinum-sensitive ovarian cancer across select nonclinical attributes: Europe
- Assessment of unmet need
- Key findings: unmet need in advanced platinum-sensitive ovarian cancer
- Surveyed medical oncologistsu2019 satisfaction with the performance of key therapies for advanced platinum-sensitive ovarian cancer on efficacy, safety and tolerability, convenience of administration, and nonclinical factors: United States
- Surveyed medical oncologistsu2019 satisfaction with the performance of key therapies for advanced platinum-sensitive ovarian cancer on efficacy, safety and tolerability, convenience of administration, and nonclinical factors: Europe
- Surveyed medical oncologists' ascribed level of unmet need across key efficacy attributes in advanced platinum-sensitive ovarian cancer: United States
- Surveyed medical oncologists' ascribed level of unmet need across key efficacy attributes in advanced platinum-sensitive ovarian cancer: Europe
- Surveyed medical oncologists' ascribed level of unmet need across key safety and tolerability attributes in advanced platinum-sensitive ovarian cancer: United States
- Surveyed medical oncologists' ascribed level of unmet need across key safety and tolerability attributes in advanced platinum-sensitive ovarian cancer: Europe
- Surveyed medical oncologists' ascribed level of unmet need across key convenience of administration attributes in advanced platinum-sensitive ovarian cancer: United States
- Surveyed medical oncologists' ascribed level of unmet need across key convenience of administration attributes in advanced platinum-sensitive ovarian cancer: Europe
- Surveyed medical oncologists' ascribed level of unmet need across key nonclinical factors in advanced platinum-sensitive ovarian cancer: United States
- Surveyed medical oncologists' ascribed level of unmet need across key nonclinical factors in advanced platinum-sensitive ovarian cancer: Europe
- Key findings: unmet need in advanced platinum-sensitive ovarian cancer and related indications
- Surveyed medical oncologists' ascribed level of unmet need in advanced platinum-sensitive ovarian cancer and related indications: United States
- Surveyed medical oncologists' ascribed level of unmet need in advanced platinum-sensitive ovarian cancer and related indications: Europe
- Opportunity analysis
- Areas of opportunity in the advanced platinum-sensitive ovarian cancer market and emerging therapy insights
- Opportunity: a novel therapy offering a substantial overall survival benefit
- Opportunity: a novel therapy that improves progression-free survival
- Opportunity: a novel therapy with an improved safety and tolerability profile
- Opportunity: a novel therapy with a predictive biomarker of response
- Areas of opportunity in the advanced platinum-sensitive ovarian cancer market and emerging therapy insights
- Target product profiles
- Assessing drug development opportunities
- Target product profile methodology
- Attributes and attribute levels
- Assigned prohibitions for the conjoint module
- Attribute importance and part-worth utilities
- First-line advanced platinum-sensitive ovarian cancer, regardless of BRCA or HRD status target product profile: attribute importance
- Median overall survival (months)
- Median progression-free survival (months)
- Objective response rate (% of patients)
- Incidence of grade 3/4 hematological toxicities (% of patients)
- Incidence of any grade gastrointestinal toxicities (% of patients)
- Incidence of any grade general toxicities (% of patients)
- Price per 21-day cycle (induction and/or maintenance)
- Conjoint analysis-based simulation of a market scenario
- First-line advanced platinum-sensitive ovarian cancer, regardless of BRCA or HRD status market simulation: share of preference of target product profiles included in the market scenario
- First-line advanced platinum-sensitive ovarian cancer, regardless of BRCA or HRD status market simulation: likelihood to prescribe of target product profiles included in the market scenario
- First-line advanced platinum-sensitive ovarian cancer, regardless of BRCA or HRD status market simulation: target product profiles included in the market scenario
- Appendix
- Key abbreviations
- Bibliography
- Executive summary
Rajashri Lella, M.Pharm., Associate Healthcare Research & Data Analyst, Oncology. Ms. Lella performs secondary market research, which includes patent research and pricing for major pharmaceutical markets covering multiple oncology indications. She previously worked on Clarivate’s Oncology Clinical Trial Monitor. Ms. Lella completed a master’s degree in pharmaceutical quality assurance at Manipal Academy of Higher Education in India.
Julia Morris, Ph.D., Healthcare Research & Data Analyst, Oncology. Before joining Clarivate, she was a senior bioscientist in the Drug Discovery Unit at Cancer Research UK Manchester Institute. During this time, she developed and conducted assays to assess the effect of preclinical small-molecule inhibitors on in vitro cellular proliferation in breast, ovarian, and uterine cancer cell lines. She earned her Ph.D. in molecular biology from the University of Sheffield and a B.Sc in cellular and molecular medicine with study in industry from the University of Bristol.