Obesity is a significant public health concern in the United States and Europe. Its chronic progression is associated with type 2 diabetes and adverse cardiovascular (CV) health. Following a series of high-profile market withdrawals, the obesity drug landscape has seen several new treatments launch since 2012, but uptake of these agents has been slow, suggesting suboptimal risk-benefit profiles and reflecting the poor reimbursement environment for prescription weight-loss agents. In this report, endocrinologists compare current antiobesity drugs and discuss the attributes that the next generation of drugs should have to serve this medically important population and to succeed commercially in a potentially lucrative market.
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with the United States and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.
Markets covered: United States, United Kingdom, France, Germany
Primary research: Survey of 60 U.S. and 30 European endocrinologists fielded in February 2021
Key companies: Novo Nordisk, Vivus, Currax Pharmaceuticals, Orexigen Therapeutics
Key drugs: Saxenda, Qsymia, Contrave/Mysimba, Xenical, phentermine