Asthma | Unmet Need | Severe Asthma | US/EU | 2020

Several effective anti-inflammatory agents and bronchodilators are available for controlling patients’ mild or moderate asthma. However, despite the entry of LAMAs (e.g., BI’s Spiriva) and novel biologics (e.g., AstraZeneca’s Fasenra, Teva’s Cinqair, Sanofi / Regeneron’s Dupixent, GSK’s Nucala) in the market, an unmet need remains for effective therapies for severe disease, especially for patients whose symptoms are not adequately controlled with current therapies or who depend on frequent SABA and/or oral corticosteroid use to achieve relief. This “Unmet Need” report provides quantitative insights into key treatment drivers and goals and the current level of unmet need in severe asthma, based on the perceptions of U.S. and European physicians. We analyze the commercial opportunities and how emerging therapies may capitalize on these opportunities.

Questions Answered

  • What are the treatment drivers and goals for severe asthma?
  • What attributes are key influencers, which have limited impact, and which are hidden opportunities?
  • How do current inhaled (e.g., Spiriva) and biological (e.g., Dupixent, Nucala) therapies perform on key treatment drivers and goals in severe asthma?
  • What are the prevailing areas of unmet need and opportunity in severe asthma?
  • What trade-offs across different clinical attributes and prices are acceptable to U.S. and European physicians for a hypothetical new drug targeting severe asthma?


United States, France, Germany, United Kingdom

Primary Research

Survey of approximately 30 U.S. pulmonologists, 30 U.S. allergists, and 30 European pulmonologists

Key Drugs Covered

Xolair, Nucala, Cinqair / Cinqaero, Fasenra, Dupixent, Spiriva (tiotropium), LABA / ICSFDCs

Key metrics included

  • Target Product Profile (TPP) simulator based on conjoint analysis methodology.
  • Stated versus derived importance of product attributes on prescribing behavior.
  • Assessment of current drug performance against treatment drivers and goals.
  • Physician perceptions of unmet needs in the indication and related indications.
  • Analysis of remaining drug development opportunities.

Product Description

“Unmet Need” supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.

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