IBS-D is a highly prevalent disorder regularly encountered in general practice that is marked by excessive defecation and abdominal pain/discomfort. Currently, its etiology and pathophysiology are poorly characterized, and there are no objective means to diagnose the disease (e.g., a biomarker), guide development of new therapeutic approaches, or target IBS-D patients who are likely to respond adequately to treatment. Current treatments for IBS-D and clinical investigations of new therapies focus on amelioration of symptoms (e.g., decreased pain, reduced frequency of defecation). However, this market is highly underserved, with the majority of available agents offering suboptimal efficacy or being associated with undesirable side effects. Thus, unmet need is high in this indication, leaving significant commercial opportunity for novel IBS-D therapies.
The Unmet Need content provides quantitative insight into U.S. and European physician perceptions of key treatment drivers and goals and the current level of unmet need in IBS-D. We analyze the commercial opportunities in the IBS-D therapy market and discuss how emerging therapies may be able to capitalize on these opportunities.