Axial Spondyloarthritis – Unmet Need – Axial Spondyloarthritis | Unmet Need | Ankylosing Spondylitis | US/EU | 2022
In the last 20 years, TNF-α inhibitors (AbbVie’s Humira, Amgen / Pfizer’s Enbrel, Janssen’s Remicade and Simponi, UCB’s Cimzia) have transformed the treatment of ankylosing spondylitis (AS) and brought new attention to this autoimmune disease. The IL-17 inhibitors (Novartis’s Cosentyx and Eli Lilly’s Taltz) offer an alternative mechanism of action to TNF-α inhibition and are relatively new to the market. Today, oral targeted therapies—e.g., JAK inhibitors (AbbVie’s Rinvoq and Pfizer’s Xeljanz)—are approved for AS; these agents’ success will be shaped by the remaining unmet needs in the treatment of this population. In this report, we examine areas of unmet need in the treatment of AS, including short-term efficacy, patients’ quality of life, mechanism of action, safety and tolerability, delivery, and price. With quantitative insight into U.S. and European rheumatologists’ assessment of the unmet need in AS, we discuss the commercial opportunities for this enigmatic indication and how emerging therapies may capitalize on these opportunities.
QUESTIONS ANSWERED
- What are the treatment drivers and goals for AS?
- What drug attributes are key influencers, which have limited impact, and which are hidden opportunities?
- How do current therapies perform on key treatment drivers and goals for AS?
- What are the prevailing areas of unmet need and opportunity in AS?
- What trade-offs across different clinical attributes and price are acceptable to U.S. and European rheumatologists for a hypothetical new AS drug?
PRODUCT DESCRIPTION
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by Clarivate experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.
Markets covered: United States, France, Germany, United Kingdom
Primary research: Survey of 60 U.S. and 30 European rheumatologists fielded in February 2022.
Key companies: AbbVie, Amgen, Janssen, UCB, Novartis, Eli Lilly
Key drugs: Humira, Enbrel, Remicade, Cimzia, Cosentyx, Taltz, Rinvoq
Table of contents
- Axial Spondyloarthritis - Unmet Need - Axial Spondyloarthritis | Unmet Need | Ankylosing Spondylitis | US/EU | 2022
- Unmet Need - Ankylosing Spondylitis - TPP Simulator - April 2022
- Executive summary
- Introduction
- Treatment drivers and goals
- Key findings: attribute importance
- Relative importance of efficacy, safety and tolerability, convenience of administration, and nonclinical attributes to surveyed rheumatologists' prescribing decisions in ankylosing spondylitis
- Importance of efficacy attributes to prescribing decisions in ankylosing spondylitis: United States
- Importance of efficacy attributes to prescribing decisions in ankylosing spondylitis: Europe
- Importance of safety and tolerability attributes to prescribing decisions in ankylosing spondylitis: United States
- Importance of safety and tolerability attributes to prescribing decisions in ankylosing spondylitis: Europe
- Importance of convenience of administration attributes to prescribing decisions in ankylosing spondylitis: United States
- Importance of convenience of administration attributes to prescribing decisions in ankylosing spondylitis: Europe
- Importance of nonclinical factors to prescribing decisions in ankylosing spondylitis: United States
- Importance of nonclinical factors to prescribing decisions in ankylosing spondylitis: Europe
- Key findings: stated vs. derived importance
- Stated vs. derived importance of key efficacy, safety and tolerability, convenience of administration, and nonclinical attributes to prescribing decisions in ankylosing spondylitis: United States
- Stated vs. derived importance of key efficacy, safety and tolerability, convenience of administration, and nonclinical attributes to prescribing decisions in ankylosing spondylitis: Europe
- Product performance against treatment drivers and goals
- Key findings
- Overall performance of key therapies for ankylosing spondylitis: United States
- Overall performance of key therapies for ankylosing spondylitis: Europe
- Mean overall performance of key therapies for ankylosing spondylitis: United States and Europe
- Relative performance of key therapies for ankylosing spondylitis across select efficacy attributes: United States
- Relative performance of key therapies for ankylosing spondylitis across select efficacy attributes: Europe
- Relative performance of key therapies for ankylosing spondylitis across select safety and tolerability attributes: United States
- Relative performance of key therapies for ankylosing spondylitis across select safety and tolerability attributes: Europe
- Relative performance of key therapies for ankylosing spondylitis across select convenience of administration attributes: United States
- Relative performance of key therapies for ankylosing spondylitis across select convenience of administration attributes: Europe
- Relative performance of key therapies for ankylosing spondylitis across select nonclinical attributes: United States
- Relative performance of key therapies for ankylosing spondylitis across select nonclinical attributes: Europe
- Assessment of unmet need
- Key findings: unmet need in ankylosing spondylitis
- Surveyed rheumatologistsu2019 satisfaction with the performance of key therapies for ankylosing spondylitis on efficacy, safety and tolerability, convenience of administration, and nonclinical factors: United States
- Surveyed rheumatologistsu2019 satisfaction with the performance of key therapies for ankylosing spondylitis on efficacy, safety and tolerability, convenience of administration, and nonclinical factors: Europe
- Surveyed rheumatologistsu2019 ascribed level of unmet need across key efficacy attributes in ankylosing spondylitis: United States
- Surveyed rheumatologistsu2019 ascribed level of unmet need across key efficacy attributes in ankylosing spondylitis: Europe
- Surveyed rheumatologistsu2019 ascribed level of unmet need across key safety and tolerability attributes in ankylosing spondylitis: United States
- Surveyed rheumatologistsu2019 ascribed level of unmet need across key safety and tolerability attributes in ankylosing spondylitis: Europe
- Surveyed rheumatologistsu2019 ascribed level of unmet need across key convenience of administration attributes in ankylosing spondylitis: United States
- Surveyed rheumatologistsu2019 ascribed level of unmet need across key convenience of administration attributes in ankylosing spondylitis: Europe
- Surveyed rheumatologistsu2019 ascribed level of unmet need across key nonclinical factors in ankylosing spondylitis: United States
- Surveyed rheumatologistsu2019 ascribed level of unmet need across key nonclinical factors in ankylosing spondylitis: Europe
- Key findings: unmet need in ankylosing spondylitis and related indications
- Surveyed rheumatologistsu2019 ascribed level of unmet need in ankylosing spondylitis and related indications: United States
- Surveyed rheumatologistsu2019 ascribed level of unmet need in ankylosing spondylitis and related indications: Europe
- Opportunity analysis
- Target Product Profiles
- Appendix
Swati Kinger, M.B.A., Healthcare Research & Data Analyst, Immune and Inflammation. Ms. Kinger’s focus is the axial spondyloarthritis market. Previously, she was an associate consultant for a life sciences firm, where she worked on syndicated offerings and ad-hoc requests involving patient journeys, market assessment, and competitive intelligence. She holds a bachelor’s degree in pharmacy from Delhi University and an M.B.A. in pharmacy from the National Institute of Pharmaceutical Education and Research in India.