Axial Spondyloarthritis | Unmet Need | Ankylosing spondylitis | US/EU5 | 2020

In the last 15 years, TNF-α inhibitors (AbbVie’s Humira, Amgen / Pfizer’s Enbrel, Janssen’s Remicade and Simponi, UCB’s Cimzia) have transformed the treatment of ankylosing spondylitis (AS) and brought new attention to this autoimmune disease. Today, a second wave of biological therapies, the IL-17 inhibitors (Novartis’s Cosentyx and Eli Lilly’s Taltz), have been approved for AS; these agents’ success will be shaped by the remaining unmet needs in the treatment of this population. In this report, with quantitative insight into U.S. and European rheumatologists’ assessment of the unmet need in AS, we discuss the commercial opportunities for this enigmatic indication and how emerging therapies may capitalize on these opportunities.


  • What are the treatment drivers and goals for AS?
  • What drug attributes are key influences, which have limited impact, and which are hidden opportunities?
  • How do current therapies perform on key treatment drivers and goals for AS?
  • What are the prevailing areas of unmet need and opportunity in AS?
  • What trade-offs across different clinical attributes and price are acceptable to U.S. and European rheumatologists for a hypothetical new AS drug?


Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.

Markets covered: United States, United Kingdom, France, Germany.

Primary research: Survey of 60 U.S. and 31 European rheumatologists fielded in April 2020.

Key companies: AbbVie, Amgen, Eli Lilly, Pfizer, Janssen, UCB, Novartis.

Key drugs: Humira, Enbrel, Remicade, Cimzia, Cosentyx, Taltz.

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