Post-traumatic stress disorder (PTSD) is a chronic psychiatric condition that noticeably impairs quality of life, although only a limited proportion of newly diagnosed patients seek prescription drug treatment. A few modestly efficacious drugs are formally approved to treat PTSD; antidepressants and antipsychotics are the most commonly prescribed. Opportunity exists for emerging agents that offer improved efficacy and safety and tolerability. Improvements in efficacy include effects on core PTSD symptoms and on secondary disorders arising from PTSD (e.g., symptoms of anxiety disorders, proclivity toward substance abuse). Areas of improvement for safety and tolerability include effects such as weight gain and loss of libido. Commercial opportunity likely exists for a new PTSD drug that addresses these inadequacies and other areas of large unmet need (e.g., drugs that improve cognitive function or aid in complete remission).
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.
Markets covered: United States, United Kingdom, France, Germany
Primary research: Survey of 60 U.S. psychiatrists and 32 European psychiatrists fielded in March 2020
Key companies: GSK, Pfizer, Roche, Allergan, and AstraZeneca
Key drugs: prazosin, sertraline, paroxetine, diazepam, gabapentin, bupropion SR, and quetiapine