Neuropathic Pain | Unmet Need | Painful Diabetic Neuropathy | US/EU | 2017

Painful diabetic neuropathy (PDN), a subset of diabetic neuropathy; affects approximately seven million people in the United States and major European markets. The primary goal of treating PDN is to reduce the severity and prevent worsening of the pain while improving the patient’s QOL. The most frequently prescribed drugs for treating PDN are Lyrica (Pfizer), gabapentin (Pfizer’s Neurontin, generics), duloxetine (Eli Lilly/Boehringer Ingelheim’s Cymbalta/Xeristar, generics), Nucynta ER/Palexia SR/Yantil (Janssen/Depomed/Grünenthal), and Qutenza (Acorda/Grünenthal). The goal of treatment with all of these agents is to provide adequate analgesia to patients, each of whom may respond differently to these therapies. Despite the availability of these agents and an armamentarium of other drugs in the United States and Europe to treat PDN, opportunity remains in the PDN market for new agents that can address existing unmet needs, such as the need for products with more efficacious and safer profiles.

This Unmet Need content provides quantitative insight into U.S. and European neurologists’ perceptions of key treatment drivers and goals in the treatment of PDN and the current level of unmet need in this indication. We analyze the commercial opportunities and how emerging therapies may capitalize on these opportunities.

Questions Answered:

  • What are the treatment drivers and goals for PDN?
  • What attributes are key influencers, which have limited impact, and which are hidden opportunities?
  • How do current therapies perform on key treatment drivers and goals for PDN?
  • What are the prevailing areas of unmet need and opportunity in PDN?
  • What trade-offs across different clinical attributes and price are acceptable to U.S. and European neurologists for a hypothetical new PDN drug?

Markets covered: United States, United Kingdom, France, Germany

Primary research: Survey of 61 U.S. and 32 European neurologists fielded in December 2016

Key companies: AbbVie, Acorda Therapeutics, Astellas Pharma, Boehringer Ingelheim, Depomed, Eli Lilly, Grünenthal, Janssen, and Pfizer

Key drugs: Amitriptyline, duloxetine, gabapentin, Lyrica, Qutenza, tapentadol ER, and Vicodin

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