Numerous antidepressant therapies are available to treat major depressive disorder (MDD), many of which have long been generic and are entrenched in medical practice. However, most current therapies suffer from shortcomings in efficacy and/or safety and tolerability, resulting in inadequate patient response and remission rates and creating opportunities for new, improved therapies for treatment-resistant depression (TRD). Although newer-to-market agents such as Lundbeck / Takeda’s Trintellix / Brintellix (vortioxetine) and Janssen’s Spravato (esketamine) have expanded the armamentarium of therapeutic options and, in the case of Spravato, provided a novel, fast-acting option, unmet need remains for new therapies. This report provides quantitative insight into psychiatrists’ perceptions of key treatment drivers and goals and assesses the current level of unmet need and opportunity in the treatment of TRD.
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.
Markets covered: United States, United Kingdom, France, Germany
Primary research: Survey of 60 U.S. and 30 European psychiatrists fielded in May 2020.
Key companies: AstraZeneca, Eli Lilly, Janssen, Lundbeck, Otsuka Pharmaceutical, Takeda Pharmaceuticals
Key drugs: Aripiprazole, bupropion SR, duloxetine, quetiapine XR, Rexulti, Spravato, Trintellix / Brintellix
Key metrics provided: