According to Clarivate epidemiology, cognitive dysfunction (e.g., impaired attention / vigilance, memory, executive function) occurs in the vast majority of diagnosed schizophrenia patients and has a detrimental impact on their daily activities, occupational and social functioning, and adherence to antipsychotic treatment. Although the schizophrenia drug market is crowded, no drugs are approved specifically to treat cognitive impairment associated with schizophrenia (CIAS). Psychiatrists may prescribe off-label treatments and/or a nonpharmacological approach such as cognitive remediation, which is recommended by some recent treatment guidelines for schizophrenia; however, no therapy has demonstrated consistent efficacy in improving cognition. Although the late-phase pipeline for CIAS is sparse, Boehringer Ingelheim’s BI 425809, a glycine transporter-1 inhibitor, has had promising Phase II results and received FDA breakthrough therapy designation for CIAS. In addition, some agents with novel mechanisms of action are in early-phase development for CIAS. Overall, given the lucrative commercial potential for a drug demonstrating efficacy and safety in this underserved schizophrenia segment, it is essential for drug developers to understand the physician-perceived level of unmet need in terms of drug attributes and areas of opportunity in CIAS.
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by Clarivate experts and additional customized market scenarios can be evaluated with the corresponding TPP simulator.
Geography: United States, United Kingdom, France, Germany
Primary research: Survey of 60 U.S. and 31 European psychiatrists fielded in April 2022
Key therapies covered: Aripiprazole (oral), risperidone (oral), rivastigmine, memantine, donepezil, modafinil, nonpharmacological therapy (e.g., computer-assisted cognitive remediation)