The development of biosimilar versions of Lucentis and Eylea is of high interest in the ophthalmology market given the high cost of these agents, the large patient population suffering from retinal vascular diseases, and the need for frequent (and chronic) administration of these VEGF inhibitors to maintain/improve visual acuity. Biosimilars of ranibizumab 0.5 mg are in late-phase development and are expected to launch in the United States in 2021; Eylea’s patents are not expected to expire in the United States until 2023, so biosimilar development of aflibercept slightly lags that of ranibizumab. Avastin may not face the same threat from biosimilars in ophthalmologic indications because it is typically compounded and is already low cost. Regardless, marketers of current anti-VEGF agents and developers of emerging therapies will need to understand the potential patient-share impact of biosimilars to diversify and respond to revenue losses.
Geographies: United States
Primary research: Survey of 100 U.S. ophthalmologists, 84 of whom completed a retinal fellowship lasting at least 12 months
Key drugs covered: Avastin (Roche), Lucentis 0.3 mg and 0.5 mg (Roche), Eylea (Regeneron), FYB-201 (Bioeq/Formycon), SB-11 (Samsung Bioepis), Xlucane (Xbrane Biopharma/STADA Arzneimittel), MYL-1701P/M-710 (Mylan/Momenta Pharmaceuticals), Brolucizumab (Novartis), abicipar pegol (Allergan), faricimab (Roche), Conbercept (Chengdu Kanghong Biotech), Lucentis port-delivery system (PDS) (Roche)
Key insights provided: Physician-reported anti-VEGF treatment practices for wet AMD and DME, factors influencing choice of branded anti-VEGF agents, expected use patterns for emerging biosimilars of anti-VEGF agents in wet AMD and DME, expected impact of biosimilar anti-VEGF agents on the use of current and emerging therapies
Special Topics uses quantitative primary research to assess evolving trends and market effects in dynamic disease areas. The report examines topics of high interest to an indication, such as delving into reasons driving physicians’ prescribing decisions or assessing physicians’ receptivity to emerging agents in order to better understand the nuanced dynamics in the indication.