Polycystic Kidney Disease – Special Topics – Special Topic: Assessment & Forecast – US, EU5, Japan, China
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the development and progressive enlargement of fluid-filled cysts in the kidneys. Particularly in the early stages, the disease is often asymptomatic and detectable only through diagnostic imaging of the kidney to reveal cysts. The launch of Otsuka’s Jynarque / Jinarc / Samsca (tolvaptan) introduced the first disease-specific therapy for ADPKD. However, several therapies are being investigated in clinical trials, including Sanofi / Genzyme’s venglustat, Reata Pharmaceuticals’ bardoxolone methyl, Palladio Bioscience’s lixivaptan, and Regulus Therapeutics’ RGLS-4326. These therapies are forecast to fulfill several of the unmet needs that remain. These unmet needs include superior efficacy and safety / tolerability compared to tolvaptan, and prescribing to a greater range of patients (e.g., those with elevated liver enzymes).
QUESTIONS ANSWERED
- What do key opinion leaders think about the emerging therapies Sanofi / Genzyme’s venglustat, Reata Pharmaceuticals’ bardoxolone methyl, Palladio Bioscience’s lixivaptan, Regulus Therapeutics’ RGLS-4326, XORTX Therapeutics’ oxipurinol, and Galapagos’ GLPG2737? What is the likelihood that these drugs will launch? How will emerging therapies differentiate themselves in an increasingly crowded market?
- How will the anticipated genericization of Otsuka’s Jynarque / Jinarc / Samsca affect the uptake of the branded and emerging therapies?
- What are the different reimbursement challenges that ADPKD therapies face in the United States, Europe, Japan, and China?
- What are the key unmet needs in ADPKD, and how likely are they to be met?
Geographies:
- United States, EU5, Japan, China
Primary research:
- 20 country-specific interviews with thought-leading nephrologists
- Supported by survey data collected for this and other DRG research
Epidemiology
- Diagnosed, and drug-treated prevalent cases of ADPKD by country.
Forecast
- 15-year, annualized, drug-level sales and patient share of key ADPKD therapies through 2020, segmented by brands / generics and epidemiological subpopulations.
Emerging therapies
- Phase III/PR: 3 drugs; Phase I/II: 3 drugs
PRODUCT DESCRIPTION
Special Topic: Market Assessment & Forecast provides market intelligence with world-class epidemiology, insight into current and future treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
David Rees, M.Biochem., Ph.D., is a senior analyst on the Cardiovascular, Metabolic, Renal, and Hematologic (CMRH) Disorders team at Clarivate. He has authored reports on osteoporosis, autosomal dominant polycystic kidney disease, pulmonary hypertension, and type 2 diabetes. Previously, he was a postdoctoral research associate at Imperial College London and the Institute of Cancer Research. For his doctoral research, he studied the structures of molecular machines in the Nobel Prize-winning laboratory of Prof. Sir John Walker at the University of Cambridge. Dr. Rees earned his undergraduate degree at the University of Bath.
Graeme Green, M.Sc., Ph.D., is the head of the Cardiovascular, Metabolic, Renal, and Hematology (CMRH) group at Clarivate, where he leads a team of analysts investigating indications ranging from type 2 diabetes to chronic heart failure. With more than 14 years of market experience in this space, he has managed and authored a vast array of content. Using various forecasting and assessment methodologies, he has written indication-specific insight reports and provided analysis on market dynamics, drug development, and corporate strategy. Prior to moving to the pharmaceutical sector, he worked for a financial management consultancy. Dr. Green holds a Ph.D. in molecular medical microbiology and an M.Sc. in forensic science from King’s College London.