Core to Parkinson’s disease (PD) treatment is the co-prescription of various formulations of the gold-standard SOC levodopa with a range of adjunctive therapies from other drug classes (e.g., dopamine agonists, MAO-B inhibitors) to address breakthrough motor symptoms. Pipeline therapies seek to improve therapeutic experience and motor symptom benefit through novel mechanisms, delivery routes, and simplified dosing regimens. The use of newer brands (e.g., Rytary [Amneal], Gocovri [Supernus], Inbrija [Acorda]) has steadily grown, but these agents will face competition from emerging reformulations (e.g., ABBV-951 [AbbVie]) and new molecular entities (NMEs) (IPX-203 [Amneal], dipraglurant [Addex], tavapadon [Cerevel]) in established classes; these reformulations and NME’s have the potential to radically change the clinical management and commercial outlooks in PD. Understanding physicians’ receptivity and anticipated use for new entrants is crucial for developers advancing new drugs in the increasingly crowded, largely generic, and clinically complex market.
Clarivate’s Special Topics reports use quantitative and/or qualitative primary research to assess evolving trends and market effects in dynamic disease areas. Insights from this report will help developers gauge the competitiveness and sales potential of late-phase assets in the PD market.