Alopecia areata (AA) is an inflammatory autoimmune skin disease characterized by varying degrees of hair loss. The host immune system targets anagen hair follicles. The primary goal of treatment is to stimulate hair growth by reducing the inflammation at sites of hair loss. Topical / intralesional corticosteroids and topical immunotherapy are commonly prescribed for AA; however, tolerability issues, side effects, and the modest efficacy of these treatments underscore the substantial unmet clinical need in AA. The AA pipeline is active, consisting primarily of targeted immunomodulatory agents, and boasts several marketed and investigational JAK inhibitors (e.g., Eli Lilly’s Olumiant, Pfizer’s ritlecitinib, Concert’s CTP-543). This report provides an analysis of AA epidemiology, current disease management, unmet needs, and the clinical and commercial potential of emerging AA therapies.
Niche & Rare Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.