Scleroderma (Systemic Sclerosis) | Niche & Rare Disease Landscape & Forecast | US/EU5 | 2018

Scleroderma (systemic sclerosis [SSc]) is a rare progressive autoimmune disorder characterized by skin fibrosis, systemic inflammation, and varying degrees of vasculopathy that manifest as Raynaud’s disease and, often, painful digital ulcers. Risks of pulmonary arterial hypertension (PAH), interstitial lung disease (ILD), and renal crisis are higher in SSc patients than in the general population and underlie a high mortality rate. No disease-modifying therapy (DMT) has been approved to treat SSc. Systemic immunosuppressants are prescribed to treat ILD and skin fibrosis, while symptoms of PAH and vasculopathy are treated with varying combinations of calcium-channel blockers, endothelin receptor antagonists, PDE-5 inhibitors, and prostacyclin analogues. Renal crisis is treated acutely with ACE inhibitors, which interviewed experts credit with having reduced mortality from this complication. Still, current SSc treatments are only marginally effective, leaving tremendous need for effective DMTs and antifibrotics to treat this debilitating condition. Several marketed drugs (e.g., Boehringer Ingelheim’s Ofev, Roche’s Actemra/RoActemra) are in Phase III studies in SSc.


  • How many people are currentlydiagnosed with SScin the United States and EU5; how many will be diagnosed over time?
  • What is the commercial potential of key emerging therapies? How will emerging therapies fit into the SSc treatment landscape?
  • What is the current treatment landscape in SSc, and how will it change in the next ten years?
  • What do key opinion leaders consider the greatest unmet medical needs in the management of SSc?


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