Huntington’s disease (HD) is an autosomal dominant, neurodegenerative disease characterized by progressive chorea, dystonia, and cognitive decline. Current treatment is entirely focused on symptom management, and includes a cocktail of antidepressants, antipsychotics, and antiepileptics to control patients’ cognitive, behavioral, and neurological symptoms. Treatment for chorea is limited to tetrabenazine and Teva’s Austedo (deutetrabenazine), which launched in 2017. Although new HD treatments are an area of significant unmet need, the recent discontinuation of Teva’s pridopidine has left the late-stage pipeline devoid of candidates. However, the Phase II pipeline includes a variety of symptom-targeting and potential disease-modifying therapies, which could capitalize on the significant commercial opportunity that exists if they can demonstrate efficacy in HD patients.
Niche & Rare Disease Landscape & Forecast: comprehensive market intelligence providing world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.