Primary sclerosing cholangitis (PSC) is a chronic, idiopathic cholangiopathy that can progress to cirrhosis, end-stage liver disease, hepatobiliary cancer, and/or colon cancer. The median age of diagnosis is 42 years, and it is more common in men than in women. Despite the severity of PSC, no therapies are approved to treat it. Current treatment with UDCA and fenofibrates offers some clinical benefit but does not prevent the progression to liver cirrhosis or cholangiocarcinoma. However, several therapies with novel mechanisms of action are in development to treat PSC and will be used first line if they prove safe and efficacious. These therapies will capitalize on the immense unmet need in this space.
Executive Insights provides indication-specific market intelligence with world-class epidemiology, keen insight into current treatment paradigms, biotherapeutic pipelines, key clinical unmet needs, and competitive landscapes, supported by primary and secondary research. This solution provides succinct insights to any biopharma function or business professional looking to quickly grasp a new indication of interest.