Dupixent (Sanofi/Regeneron), a first-in-class biologic that inhibits IL-4/IL-13 signaling, was approved for the treatment of eosinophilic asthma and oral-corticosteroid-dependent asthma in October 2018. Because it competes with three previously approved anti-IL-5 agents (GlaxoSmithKline’s Nucala, Teva’s Cinqair, and AstraZeneca’s Fasenra) for the eosinophilic asthma patient population and with an anti-IgE agent Xolair (Roche) for a subset of severe allergic and eosinophilic asthmatics, physician assessment of Dupixent’s performance will provide Sanofi and Regeneron, their competitors, and companies developing therapies targeting severe asthma with insight regarding its market uptake.
This Asthma Emerging Therapies series tracks the awareness, trial, and use of Dupixent by U.S. pulmonologists and allergists over a year’s time. Additionally, the series examines physician-anticipated trends in asthma treatment, particularly Dupixent’s uptake, and assesses Sanofi’s and Regeneron’s promotional efforts.
Key Metrics Included
Emerging Therapies captures U.S. physicians’ awareness, perceptions, and usage of the launched product at one, six, and twelve months postlaunch, as well as the current and future impact on competitor therapies and the overall market. Insight is also provided on promotional efforts, prescriber and nonprescriber profiles, benchmarking against other launched agents, along with statistical comparative analysis with prior waves so that marketers can track and optimize the effectiveness of their launch strategy or fine-tune their product positioning to counter its impact on their brand’s share.