Dry and Wet Age-Related Macular Degeneration | Disease Landscape & Forecast | G7 | 2021

The wet age-related macular degeneration (AMD) therapy market has long been dominated by three VEGF inhibitors—Roche / Genentech / Chugai’s Avastin, Roche / Genentech / Novartis’s Lucentis, and Regeneron / Bayer HealthCare / Santen’s Eylea—but competition has intensified since the U.S. approval of Novartis’s Beovu in late 2019. We expect this launch to be followed by six other late-phase therapies for wet AMD, and biosimilars are on the horizon; thus, Eylea’s and Lucentis’s positions will be increasingly threatened as the market becomes more fragmented. In contrast to the treatment of wet AMD, management of patients with dry AMD is limited to minimally effective vitamin formulations because no prescription therapies are approved for this large and underserved subpopulation. However, several novel therapies are advancing in the pipeline for dry AMD, increasing the possibility that an effective therapy may soon emerge. Questions Answered:

  • Do KOLs perceive any differences between Avastin, Eylea, Lucentis, and Beovu? How is the wet AMD treatment algorithm expected to change, if at all, as new products launch?
  • Biosimilar versions of Eylea and Lucentis are forecast to launch within the next five years. What is the likely impact of these therapies on current and emerging VEGF inhibitors?
  • A substantial unmet need in wet AMD exists for therapies with longer dosing intervals than those offered by current therapies. To what extent are late-phase therapies such as Roche’s ranibizumab port delivery system and faricimab expected to capitalize on this unmet need?
  • With the anticipated approval of Apellis’s pegcetacoplan and IVERIC Bio’s Zimura as the first drugs for GA, how likely are these complement inhibitors to be incorporated into clinical practice?

Product Description: Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research. Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, and Japan. Primary research: 31 country-specific interviews with thought-leading retinal specialists. Supported by survey data collected for this and other DRG research. Epidemiology: Total prevalence of late AMD by country, segmented by GA and wet AMD subpopulations, including diagnosed and drug-treated rates. Forecast: Ten-year, annualized, drug-level sales and patient share of key GA and wet AMD therapies through 2029, segmented by brands / biosimilars and epidemiological subpopulations. Emerging therapies: Phase III / PR: 12 drugs; Phase II: 12 drugs; coverage of select Phase I products.

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