Bladder Cancer | Disease Landscape and Forecast | G7 | 2018
Immune checkpoint inhibitors are revolutionizing the treatment algorithm for unresectable locally advanced or metastatic bladder cancer. Following the 2016/7 FDA approvals of five immune checkpoint inhibitors for platinum-treated patients (i.e., second– and later lines)—PD-L1 inhibitor Tecentriq (Roche/Genentech/Chugai) followed by PD-1 inhibitor Opdivo (Bristol-Myers Squibb) and other PD-1/PD-L1 inhibitors—significant sales are forecast for the unresectable locally advanced or metastatic setting. There is now intense Phase II/III pipeline activity, with some drugs in the late-phase pipeline also targeting previously untreated unresectable locally advanced or metastatic bladder cancer (i.e., first-line setting). We anticipate that several new therapies will gain approvals within the forecast period, resulting in increased therapy options.
How large are the clinically and commercially relevant drug-treatable unresectable locally advanced or metastatic bladder cancer populations and how will drug-treatment rates change over time?
What is the current state of treatment for unresectable locally advanced or metastatic bladder cancer? What are the (dis)advantages of currently marketed drugs and interviewed experts’ insights on these therapies?
What clinical needs remain unfulfilled and what opportunities can developers capitalize on?
What pipeline products are most promising, and what sales/uptake could they secure in the unresectable locally advanced or metastatic bladder cancer market? What are the most promising early-phase pipeline products?
What are the drivers and constraints in the unresectable bladder cancer market, and how will the market evolve over the ten-year forecast period within the major markets?
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