Clarivate expects the market for NASH, a severe form of nonalcoholic fatty liver disease (NAFLD), to become lucrative owing to the lack of approved agents and the disease’s large and growing prevalence. The body of evidence for the significant burden the disease places on healthcare systems is accumulating, particularly with respect to the increased risk of cardiovascular disease, liver failure, and NASH’s potential to quickly become the leading reason for liver transplantation. The lack of treatment options and limited awareness of the disease and its complications have kept diagnosis and treatment rates low. Despite guidelines recommending certain off-label medications, prescribing is usually limited to specialists caring for patients with more-advanced disease. However, with more education about the disease, development of novel diagnostic tools, and approved medical therapies becoming available, diagnosis and treatment rates will increase and drive growth of the overall market. Over the 2021-2031 forecast period, the NASH market will see launches of the first agents from a rich pipeline of emerging therapies, which will fuel huge market expansion.
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