Atopic Dermatitis / Atopic Eczema – Landscape & Forecast – Disease Landscape & Forecast

Atopic dermatitis (AD) is a chronic inflammatory skin disease marked by pruritus and eczema. Key goals of AD treatment are to protect the skin barrier, reduce inflammation, and alleviate itch. Topical therapies are often effective for mild disease but have suboptimal safety, tolerability, and compliance. More-effective therapies for topical-refractory patients and, more generally, those with moderate to severe AD are a key focus of the robust drug development driving the AD market revolution. This upheaval began with the 2017 launches of Sanofi / Regeneron’s injectable biologic Dupixent (dupilumab) and Pfizer’s nonsteroidal topical cream Eucrisa / Staquis (crisaborole). Since then, seven additional agents have been approved: three oral JAK inhibitors (Eli Lilly’s Olumiant [baricitinib], AbbVie’s Rinvoq [upadacitinib], and Pfizer’s Cibinqo [abrocitinib]); three nonsteroidal topical agents (Japan Tobacco’s Corectim [delgocitinib], Incyte’s Opzelura [ruxolitinib], and Otsuka & Medimetriks’ Moizerto [difamilast]); and LEO Pharma’s targeted biologic Adbry / Adtralza (tralokinumab). This report provides a comprehensive analysis of AD patient populations, current disease management, lingering unmet needs, and the clinical and commercial potential of current and emerging drugs.

QUESTIONS ANSWERED

  • What are the sizes of the mild, moderate, and severe AD subpopulations, and how will they change by 2031? How well are these subpopulations served by current AD therapies?
  • How have Eucrisa and Dupixent been incorporated into the AD treatment algorithm? What market niches are recently launched JAK inhibitors, topicals, and biologics likely to occupy?
  • What therapies are in development for AD? Of these therapies, which are best poised to achieve commercial success?
  • What are the greatest unmet needs in the treatment of AD, and to what degree will therapies in the pipeline address these needs?

PRODUCT DESCRIPTION

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

SOLUTION ENHANCEMENT

Disease Landscape & Forecast will feature continual updates in 2022 to provide timely insights and analyses as meaningful indication-specific news and events unfold. Additionally, Disease Landscape & Forecast introduces a new Drug Pipeline chapter with real-time, global pipeline intelligence content directly from Cortellis. This chapter is updated daily and features interactive figures that can be easily downloaded for detailed analysis or presentations.

Content highlights:

Geographies: United States, France, Germany, Italy, Spain, United Kingdom, and Japan.

Primary research: Approximately 16 country-specific interviews with thought leaders. Supported by survey data collected for this and other Clarivate research.

Epidemiology: Diagnosed and drug-treated prevalence of atopic dermatitis by country, 12-month total prevalence of atopic dermatitis by severity.

Emerging therapies: Phase III/PR: 5 drugs; Phase II: ~22 drugs; coverage of select early-phase products.

Forecast: 10-year, annualized, drug-level sales and patient share of key atopic dermatitis therapies through 2031, segmented by brands / generics, disease severity, and pediatric / adult subpopulations.

Table of contents

  • Atopic Dermatitis / Atopic Eczema - Landscape & Forecast - Disease Landscape & Forecast
    • Key Updates
      • Q3 2022
        • August 2022
        • July 2022
      • Q2 2022
        • June 2022
        • May 2022
        • April 2022
      • Q1 2022
        • March 2022
        • February 2022
        • January 2022
      • Q4 2021
        • December 2021
        • October 2021
      • Q3 2021
        • September 2021
        • August 2021
        • July 2021
    • Key Findings
      • Atopic Dermatitis - Key Findings - June 2022 Updated
        • September 2021
        • August 2021
        • July 2021
    • Commercial Outlook
      • Key Findings
        • Market Share of Drug Classes for Atopic Dermatitis: 2020
        • Market Share of Drug Classes for Atopic Dermatitis: 2030
        • Atopic Dermatitis SWOT Analysis
      • COVID-19: Market Forecast Impact
        • Market Drivers and Constraints
          • What Factors Are Driving the Market for Atopic Dermatitis?
          • What Factors Are Constraining the Market for Atopic Dermatitis?
        • Drug-Class-Specific Trends
          • Major-Market Sales of IL-4 / IL-13 Inhibitors: 2020-2030
          • Major-Market Sales of IL-31 Inhibitors: 2020-2030
          • Major-Market Sales of JAK Inhibitors: 2020-2030
          • Major-Market Sales of Topical JAK Inhibitors: 2020-2030
          • Major-Market Sales of Topical Phosphodiesterase-4 Inhibitors: 2020-2030
          • Major-Market Sales of Topical Calcineurin Inhibitors: 2020-2030
      • Forecast
        • Market Forecast Assumptions
        • Market Forecast Dashboard
      • Etiology and Pathophysiology
        • Disease Overview
          • Clinical Presentation
            • Atopic Dermatitis Risk and Protective Factors
              • Key Risk Factors for Atopic Dermatitis
              • Protective Factors in Atopic Dermatitis
            • Social and Economic Burden of Atopic Dermatitis
              • Atopic Dermatitis Comorbidities
            • Cutaneous Immunity
              • The Skin Barrier
                • Skin Barrier Defects
                  • Key Skin Barrier Proteins Mutated in Atopic Dermatitis
                • Altered Immune Reactivity and the Skin Microbiome
                  • Key Pathways and Drug Targets
                  • Epidemiology Overview
                    • Key Findings
                      • Key Updates
                    • Epidemiology Populations
                      • Disease Definition
                      • Methods
                      • Sources Used for Prevalence of Atopic Dermatitis
                      • Total Prevalent Cases of Atopic Dermatitis: 2020-2030
                      • Disease Definition
                      • Methods
                      • Sources Used for Severity of 12-Month Total Prevalent Atopic Dermatitis
                      • 12-Month Total Prevalent Cases of Atopic Dermatitis by Severity: 2020-2030
                      • Diagnosed Prevalent Cases of Atopic Dermatitis: 2020-2030
                      • Disease Definition
                      • Methods
                      • Sources Used for Severity of Diagnosed 12-Month Prevalent Atopic Dermatitis
                      • Number of Diagnosed 12-Month Total Prevalent Cases of Atopic Dermatitis in the Major Pharmaceutical Markets by Severity: 2020-2030
                      • Drug-Treated Diagnosed Prevalent Cases of Mild Atopic Dermatitis: 2020-2030
                      • Drug-Treated Diagnosed Prevalent Cases of Moderate Atopic Dermatitis: 2020-2030
                      • Drug-Treated Diagnosed Prevalent Cases of Severe Atopic Dermatitis: 2020-2030
                  • Current Treatment
                    • Key Findings
                      • Treatment Goals
                        • Key Endpoints Used in Clinical Trials for Atopic Dermatitis
                      • Key Current Therapies
                        • Overview
                        • Mechanism of Action of Key Current Drugs Classes Used for Atopic Dermatitis
                        • Current Treatments Used for Atopic Dermatitis
                        • Market Events Impacting the Use of Key Current Therapies for Atopic Dermatitis
                        • Clinical Trial Outcomes for Cibinqo
                        • Advantages and Disadvantages of Cibinqo
                        • Key Results From Select Clinical Trials Investigating Cibinqo for the Treatment of Atopic Dermatitis
                        • Ongoing Clinical Development of Cibinqo
                        • Key Ongoing Clinical Trials of Cibinqo in the Treatment of Atopic Dermatitis
                        • Expert Insight: Cibinqo
                        • Rinvoq
                        • Clinical Trial Outcomes for Rinvoq
                        • Advantages and Disadvantages of Rinvoq
                        • Key Results From Select Clinical Trials Investigating Rinvoq for the Treatment of Atopic Dermatitis
                        • Ongoing Clinical Development of Rinvoq
                        • Key Ongoing Clinical Trials of Rinvoq in the Treatment of Atopic Dermatitis
                        • Expert Insight: Rinvoq
                        • Olumiant
                        • Advantages and Disadvantages of Olumiant
                        • Key Results From Select Clinical Trials Investigating Olumiant for the Treatment of Atopic Dermatitis
                        • Ongoing Clinical Development of Olumiant
                        • Key Ongoing Clinical Trials of Olumiant in the Treatment of Atopic Dermatitis
                        • Expert Insight: Olumiant
                        • Advantages and Disadvantages of Eucrisa / Staquis
                        • Key Results From Select Phase III or Phase IV Clinical Trials of Eucrisa / Staquis for the Treatment of Atopic Dermatitis
                        • Ongoing Clinical Development of Eucrisa / Staquis
                        • Key Ongoing Clinical Trials of Eucrisa / Staquis in the Treatment of Atopic Dermatitis
                        • Expert Insight: Eucrisa / Staquis
                        • Moizerto
                        • Advantages and Disadvantages of Moizerto
                        • Key Results From Select Clinical Trials Investigating Moizerto for the Treatment of Atopic Dermatitis
                        • Ongoing Clinical Development of Moizerto
                        • Expert Insight: Moizerto
                        • Adbry / Adtralza
                        • Advantages and Disadvantages of Adbry / Adtralza
                        • Key Results From Select Clinical Trials Investigating Adbry / Adtralza for the Treatment of Atopic Dermatitis
                        • Ongoing Clinical Development of Adbry / Adtralza
                        • Key Ongoing Clinical Trials of Adbry / Adtralza in the Treatment of Atopic Dermatitis
                        • Expert Insight: Adbry / Adtralza
                        • Advantages and Disadvantages of Dupixent
                        • Outcomes From Key Phase III Clinical Trials of Dupixent
                        • Ongoing Clinical Development
                        • Key Ongoing Clinical Trials of Dupixent in the Treatment of Atopic Dermatitis
                        • Expert Insight: Use of Dupixent in the Treatment of Atopic Dermatitis
                        • Advantages and Disadvantages of Opzelura
                        • Clinical Trial Outcomes for Opzelura
                        • Key Results From Select Clinical Trials Investigating Opzelura for the Treatment of Atopic Dermatitis
                        • Ongoing Clinical Development of Opzelura
                        • Key Ongoing Clinical Trials of Opzelura in the Treatment of Atopic Dermatitis
                        • Expert Insight: Opzelura
                        • Corectim
                        • Advantages and Disadvantages of Corectim
                        • Key Results From Clinical Trials Investigating Corectim for the Treatment of Atopic Dermatitis
                        • Ongoing Clinical Development of Corectim
                        • Expert Insight: Corectim
                        • Advantages and Disadvantages of Pimecrolimus
                        • Expert Insight: Use of Pimecrolimus in the Treatment of Atopic Dermatitis
                        • Advantages and Disadvantages of Topical Tacrolimus
                        • Expert Insight: Use of Topical Tacrolimus in the Treatment of Atopic Dermatitis
                        • Potency and Formulations of Corticosteroids Commonly Used in the Treatment of Atopic Dermatitis
                        • Advantages and Disadvantages of Topical Corticosteroids
                        • Expert Insight: Use of Topical Corticosteroids in the Treatment of Atopic Dermatitis
                        • Advantages and Disadvantages of Conventional Oral Immunosuppressants
                        • Expert Insight: Use of Conventional Oral Immunosuppressants in the Treatment of Atopic Dermatitis
                        • Advantages and Disadvantages of Emollients
                        • Expert Insight: Use of Emollients in the Treatment of Atopic Dermatitis
                        • Advantages and Disadvantages of Phototherapy
                        • Expert Insight: Use of Phototherapy in the Treatment of Atopic Dermatitis
                      • Medical Practice
                        • Overview
                        • Factors Influencing Drug Selection in Atopic Dermatitis
                        • Treatment Decision Tree for Atopic Dermatitis: United States
                        • Treatment Decision Tree for Atopic Dermatitis: Europe
                        • Treatment Decision Tree for Atopic Dermatitis: Japan
                    • Unmet Need Overview
                      • Current and Future Attainment of Unmet Needs in Atopic Dermatitis
                      • Top Unmet Needs in Atopic Dermatitis: Current and Future Attainment
                      • Expert Insight: Unmet Need in Atopic Dermatitis
                    • Drug Pipeline
                      • Pipeline
                      • Regulatory Milestones
                      • Indication Comparison
                    • Emerging Therapies
                      • Key Findings
                        • Key Emerging Therapies
                          • Key Therapies in Development for Atopic Dermatitis
                          • Estimated Launch Dates of Key Emerging Therapies for the Treatment of Atopic Dermatitis
                          • Lebrikizumab Profile
                          • Key Ongoing Clinical Trials of Lebrikizumab in the Treatment of Atopic Dermatitis
                          • Analysis of the Clinical Development Program for Lebrikizumab
                          • Expert Insight: Lebrikizumab
                          • Expectations for Launch and Sales Opportunity of Lebrikizumab in Atopic Dermatitis
                          • Key Results From Select Clinical Trials Investigating Nemolizumab for the Treatment of Atopic Dermatitis
                          • Key Ongoing Clinical Trials of Nemolizumab in the Treatment of Atopic Dermatitis
                          • Analysis of the Clinical Development Program for Nemolizumab
                          • Expert Insight: Nemolizumab
                          • Expectations for Launch and Sales Opportunity of Nemolizumab in Atopic Dermatitis
                          • Tradipitant Profile
                          • Key Ongoing Clinical Trials of Tradipitant in the Treatment of Atopic Dermatitis
                          • Analysis of the Clinical Development Program for Tradipitant
                          • Expert Insight: Tradipitant
                          • Expectations for Launch and Sales Opportunity of Tradipitant in Atopic Dermatitis
                          • ARQ-151 Profile
                          • Key Ongoing Clinical Trials of ARQ-151 in the Treatment of Atopic Dermatitis
                          • Analysis of the Clinical Development Program for ARQ-151
                          • Expert Insight: ARQ-151
                          • Expectations for Launch and Sales Opportunity of ARQ-151 in Atopic Dermatitis
                          • Daleuton Profile
                          • Key Ongoing Clinical Trials of Daleuton in the Treatment of Atopic Dermatitis
                          • Analysis of the Clinical Development Program for Daleuton
                          • Expert Insight: Daleuton
                          • Expectations for Launch and Sales Opportunity of Daleuton in Atopic Dermatitis
                          • Tapinarof Profile
                          • Key Ongoing Clinical Trials of Tapinarof in the Treatment of Atopic Dermatitis
                          • Analysis of the Clinical Development Program for Tapinarof
                          • Expert Insight: Tapinarof
                          • Expectations for Launch and Sales Opportunity of Tapinarof in Atopic Dermatitis
                          • Amlitelimab Profile
                          • Analysis of the Clinical Development Program for Amlitelimab
                          • Key Ongoing Clinical Trials of Amlitelimab in the Treatment of Atopic Dermatitis
                          • Expert Insight: Amlitelimab
                          • Expectations for Launch and Sales Opportunity of Amlitelimab in Atopic Dermatitis
                          • Telazorlimab
                          • Telazorlimab Profile
                          • Key Ongoing Clinical Trials of Telazorlimab in the Treatment of Atopic Dermatitis
                          • Analysis of the Clinical Development Program for Telazorlimab
                          • Expert Insights: Telazorlimab
                          • Expectations for Launch and Sales Opportunity of Telazorlimab in Atopic Dermatitis
                        • Early-Phase Pipeline Analysis
                          • Select Compounds in Early-Phase Development for Atopic Dermatitis
                        • Key Discontinuations and Failures in Atopic Dermatitis
                        • Access & Reimbursement Overview
                          • Region-Specific Reimbursement Practices
                            • Key Market Access Considerations in Atopic Dermatitis: United States
                            • General Reimbursement Environment: United States
                            • Key Market Access Considerations in Atopic Dermatitis: EU5
                            • General Reimbursement Environment: EU5
                            • Key Market Access Considerations in Atopic Dermatitis: Japan
                            • General Reimbursement Environment: Japan
                        • Appendix
                          • Atopic Dermatitis Bibliography

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