Ulcerative Colitis – Landscape & Forecast – Disease Landscape & Forecast

We expect the ulcerative colitis (UC) market to grow steadily over the next decade. The availability of non-TNF biologics (e.g., Takeda’s Entyvio, Janssen’s Stelara) and the first oral JAK inhibitor (Pfizer’s Xeljanz / Xeljanz XR) have expanded physicians’ treatment armamentarium and intensified market competition. Additionally, the recent approvals of BMS’s Zeposia and Gilead / Galapagos’s Jyseleca and the expected launch of several emerging therapies with novel MOAs will drive market growth over the next decade. In balance with these factors, the continued generic erosion of conventional agents and the entry of and increased physician comfort with less expensive biosimilars will constrain the UC market and create hurdles that emerging therapies will need to overcome to secure uptake.

QUESTIONS ANSWERED

  • What are the similarities and differences in how U.S., European, and Japanese gastroenterologists treat UC?
  • How do gastroenterologists perceive biosimilar agents, and what has been/will be their impact on the UC market?
  • What are KOLs’ insights into current treatment options (e.g., Pfizer’s Xeljanz / Xeljanz XR, Janssen’s Stelara, BMS’s Zeposia, Gilead / Galapagos’s Jyseleca)? What factors drive their treatment decisions?
  • What are KOLs’ perceptions of key emerging therapies (e.g., AbbVie’s Rinvoq and Skyrizi, Janssen’s Tremfya, Eli Lilly’s mirikizumab), and where do they see these agents fitting into the treatment algorithm?

CONTENT HIGHLIGHTS

Geographies: United States, EU5, Japan.

Primary research: 34 country-specific interviews with thought-leading gastroenterologists supported by survey data collected for this and other Clarivate research.

Epidemiology: Diagnosed prevalence of UC by country, segmented by disease activity.

Forecast: Ten-year, annualized, drug-level sales and patient share of key UC therapies through 2030, segmented by brands / generics / biosimilars, and acute and maintenance settings.

Emerging therapies: Phase III/PR: ~9 drugs; coverage of select early-phase products.

PRODUCT DESCRIPTION

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

SOLUTION ENHANCEMENT

Disease Landscape & Forecast will feature continuous updates in 2022 to provide timely insights and analyses as meaningful indication-specific news and events unfold.

Table of contents

  • Ulcerative Colitis - Landscape & Forecast - Disease Landscape & Forecast
    • Key Updates
      • Q2 2022
        • April 2022
      • Q1 2022
        • March 2022
        • February 2022
        • January 2022
      • Q4 2021
        • December 2021
        • October 2021
      • Q3 2021
        • September 2021
        • August 2021
        • July 2021
      • Q2 2021
        • June 2021
        • May 2021
        • April 2021
    • Key Findings
      • Market Outlook
        • Key Findings
          • Market Share of Drug Classes for Ulcerative Colitis: 2020
          • Market Share of Drug Classes for Ulcerative Colitis: 2030
          • Patient Share of Ulcerative Colitis Therapies in the Acute Setting, by Drug Class: 2020-2030
          • Patient Share of Ulcerative Colitis Therapies in the Maintenance Setting, by Drug Class: 2020-2030
          • Ulcerative Colitis SWOT Analysis
        • Market Drivers and Constraints
          • What Factors Are Driving the Market for Ulcerative Colitis?
          • What Factors Are Constraining the Market for Ulcerative Colitis?
        • Drug-Class-Specific Trends
          • Total Sales and Patient Share of TNF-Alpha Inhibitors in Ulcerative Colitis: 2020-2030
          • Total Sales and Patient Share of Cell Adhesion Molecule Inhibitors in Ulcerative Colitis: 2020-2030
          • Total Sales and Patient Share of JAK Inhibitors in Ulcerative Colitis: 2020-2030
          • Total Sales and Patient Share of Interleukin Inhibitors in Ulcerative Colitis: 2020-2030
          • Total Sales and Patient Share of S1P-R Modulators in Ulcerative Colitis: 2020-2030
          • Total Sales and Patient Share of Other Emerging Targeted Therapies in Ulcerative Colitis: 2020-2030
      • Forecast
        • Market Forecast Assumptions
        • Market Forecast Dashboard
      • Etiology and Pathophysiology
        • Key Findings
          • Disease Overview
          • The Four Layers of the Intestinal Wall
          • Anatomical Distribution Patterns of Ulcerative Colitis
          • Typical Symptoms of Acute Ulcerative Colitis Attacks by Disease Severity
        • Etiology
          • The Immune Response
          • Select Gene Targets Associated with Ulcerative Colitis
          • Key Immune and Inflammatory Responses in Ulcerative Colitis
          • The TH2 Response
        • The Inflammatory Cascade
          • Cytokines
          • Lipid Mediators
          • Cell Adhesion Molecules
          • Janus-Activated Kinase
          • Sphingosine-1-Phosphate Receptors
          • Select Inflammatory Mediators
        • Key Pathways and Drug Targets
          • Select Drug Targets and Mechanisms of Action
          • Key Pathways and Select Drug Targets in Ulcerative Colitis
      • Epidemiology
        • Key Findings
          • Epidemiology Populations
            • Disease Definition
            • Methods
            • Sources Used for Diagnosed Prevalent Cases of Ulcerative Colitis
            • Diagnosed Prevalent Cases of Ulcerative Colitis: 2020-2030
            • Drug-Treated Prevalent Cases of Ulcerative Colitis: 2020-2030
        • Current Treatment
          • Key Findings
            • Treatment Goals
              • Key Endpoints Used in Clinical Trials for Ulcerative Colitis
            • Key Current Therapies
              • Overview
              • Mechanism of Action of Key Current Drug Classes Used for Ulcerative Colitis
              • Current Treatments Used for Ulcerative Colitis
              • Market Events Impacting the Use of Key Current Therapies for Ulcerative Colitis
              • Advantages and Disadvantages of Aminosalicylates
              • Expert Insight: Aminosalicylates
              • Advantages and Disadvantages of Corticosteroids
              • Expert Insight: Corticosteroids
              • Advantages and Disadvantages of Immunosuppressants
              • Expert Insight: Immunosuppressants
              • Advantages and Disadvantages of Infliximab
              • Advantages and Disadvantages of Adalimumab
              • Advantages and Disadvantages of Simponi
              • Expert Insight: TNF-Alpha Inhibitors
              • Advantages and Disadvantages of Entyvio
              • Expert Insight: Entyvio
              • Ongoing Clinical Development
              • Key Ongoing Clinical Trials of Entyvio in the Treatment of Ulcerative Colitis
              • Advantages and Disadvantages of Xeljanz / Xeljanz XR
              • Expert Insight: Xeljanz / Xeljanz XR
              • Key Ongoing Clinical Trials of Xeljanz / Xeljanz XR in the Treatment of Ulcerative Colitis
              • Advantages and Disadvantages of Stelara
              • Key Ongoing Clinical Trials of Stelara in the Treatment of Ulcerative Colitis
              • Advantages and Disadvantages of Zeposia
              • Key Ongoing Clinical Trials of Zeposia in the Treatment of Ulcerative Colitis
            • Medical Practice
              • Overview
              • Factors Influencing Drug Selection in Ulcerative Colitis
              • Treatment Decision Tree for Ulcerative Colitis: United States
              • Treatment Decision Tree for Ulcerative Colitis: Europe
              • Treatment Decision Tree for Ulcerative Colitis: Japan
          • Unmet Need Overview
            • Current and Future Attainment of Unmet Needs in Ulcerative Colitis
            • Top Unmet Needs in Ulcerative Colitis: Current Attainment and Future Attainment
            • Expert Insight: Unmet Need in Ulcerative Colitis
          • Drug Pipeline
            • Pipeline
            • Regulatory Milestones
          • Emerging Therapies
            • Key Findings
              • Key Emerging Therapies
                • Key Therapies in Development for Ulcerative Colitis
                • Estimated Launch Dates of Key Emerging Therapies for the Treatment of Ulcerative Colitis
                • Jyseleca Profile
                • Analysis of the Clinical Development Program for Jyseleca
                • Expectations for Launch and Sales Opportunity of Jyseleca in the Treatment of Ulcerative Colitis
                • Rinvoq Profile
                • Analysis of the Clinical Development Program for Rinvoq
                • Expectations for Launch and Sales Opportunity of Rinvoq in the Treatment of Ulcerative Colitis
                • Expert Insight: JAK Inhibitors
                • Carogra Profile
                • Analysis of the Clinical Development Program for Carogra
                • Expert Insight: Carogra
                • Expectations for Launch and Sales Opportunity of Carogra in Ulcerative Colitis
                • Etrasimod Profile
                • Analysis of the Clinical Development Program for Etrasimod
                • Expert Insight: Etrasimod
                • Expectations for Launch and Sales Opportunity of Etrasimod in the Treatment of Ulcerative Colitis
                • Mirikizumab Profile
                • Analysis of the Clinical Development Program for Mirikizumab
                • Expectations for Launch and Sales Opportunity of Mirikizumab in the Treatment of Ulcerative Colitis
                • Guselkumab Profile
                • Analysis of Clinical Development Program for Guselkumab
                • Expectations for Launch and Sales Opportunity of Guselkumab in the Treatment of Ulcerative Colitis
                • Risankizumab Profile
                • Analysis of the Clinical Development Program for Risankizumab
                • Expectations for Launch and Sales Opportunity of Risankizumab in the Treatment of Ulcerative Colitis
                • Expert Insight: IL-23 Inhibitors
                • ABX464 Profile
                • Analysis of the Clinical Development Program for ABX464
                • Expert Insight: ABX464
                • Expectations for Launch and Sales Opportunity of ABX464 in the Treatment of Ulcerative Colitis
                • Cobitolimod Profile
                • Analysis of the Clinical Development Program for Cobitolimod
                • Expert Insight: Cobitolimod
                • Expectations for Launch and Sales Opportunity of Cobitolimod in Ulcerative Colitis
              • Early-Phase Pipeline Analysis
                • Select Compounds in Phase II Development for Ulcerative Colitis
              • Key Discontinuations and Failures in Ulcerative Colitis
              • Access and Reimbursement Overview
                • Region-Specific Reimbursement Practices
                • Appendix
                  • Ulcerative Colitis Bibliography