The ulcerative colitis (UC) market is expected to grow steadily over the next decade. The anticipated entry of first-in-UC oral therapies for the moderate to severe population, together with additional emerging agents with novel MOAs and a general increase in the use of biologics to maintain disease control, will help drive market growth. In contrast to these factors, the expected generic entry of leading branded conventional agents (e.g., Shire’s Lialda), continuing generic erosion of other conventional agents, and the additional entries and expanded use of less-expensive biosimilar TNF-alpha inhibitors (e.g., Pfizer’s Inflectra, Amgen’s Amjevita) will constrain the UC market. Indeed, given the increasing competition in the UC market—for both branded and generic/biosimilar agents—emerging therapies looking to penetrate this market will need to be clearly differentiated from competitors.
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