Research Reports | Market Assessment
December 2022

Rheumatoid Arthritis | Disease Landscape & Forecast | G7 | 2022

Although the tumor necrosis factor-alpha (TNF-α) inhibitors remain the most widely prescribed biologics for rheumatoid arthritis (RA) patients refractory to conventional DMARD treatment (the first-line standard of care), the RA drug market boasts a variety of targeted agents from many drug classes, all competing largely for shares of the TNF-refractory population. The continued launch of biosimilars across the major markets will make the crowded therapy market more competitive. Increasing safety concerns about the JAK inhibitor class have pushed use of these agents to follow use of TNF-α inhibitors, primarily impacting the uptake of Xeljanz in the G7 markets. Although the late-phase pipeline is relatively sparse, the sheer number of biologics and targeted oral therapies available for RA ensures that marketers face fierce competition and increasing challenges to gain and maintain market share.

Questions answered

  • What are physicians’ preferred TNF-α inhibitors, and what factors influence this perception? Given the increasingly fragmented RA market, how likely are physicians to cycle through multiple anti-TNF agents before progressing to a novel mechanism of action?
  • What are physicians’ perceptions of the currently marketed non-TNF-α inhibitor biologics and oral JAK inhibitors, and where do these agents fit in their current treatment approach? Which of these agents has been/will be the most successful in targeting the TNF-refractory patient segment? How have the new safety warnings regarding JAK inhibitors affected physicians’ prescribing of these agents in the RA treatment algorithm?
  • How will the entry of additional novel oral therapies affect the RA treatment algorithm? In which patient segments and treatment lines will these therapies most likely be used? How will biosimilars affect sales and patient share of current RA agents and the uptake of emerging therapies?

Content highlights

Markets covered: United States, EU5, Japan.

Primary research: 30 country-specific interviews with thought-leading rheumatologists.

Epidemiology: Number of total, diagnosed, and drug-treated prevalent cases of RA by country; number of diagnosed prevalent cases of RA by severity.

Emerging therapies: Phase III/PR: 1 drug; Phase II: 8 drugs; coverage of select early-phase products.

Product description

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Solution enhancement

Disease Landscape & Forecast will feature continual updates to provide timely insights and analyses as meaningful indication-specific news and events unfold. Additionally, Disease Landscape & Forecast introduces a new Drug Pipeline chapter with real-time, global pipeline intelligence content directly from Cortellis. This chapter is updated daily and features interactive figures that can be easily downloaded for detailed analysis or presentations.

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