Psoriasis | Disease Landscape and Forecast | G7 | 2021

The psoriasis therapy market has become increasingly lucrative owing to the growing use of targeted agents. The dominance of the tumor necrosis factor (TNF)-alpha inhibitors and interleukin (IL)-12/23 inhibitor ustekinumab (Janssen’s Stelara) has been challenged by novel, highly effective IL-17 and IL-23 inhibitors. In particular, the uptake of risankizumab (AbbVie’s Skyrizi)—the latest IL-23 inhibitor to be approved for psoriasis—has been phenomenal, raising an alarm for other approved biologics. The recent and expected approvals of bimekizumab, an IL-17 inhibitor; deucravacitinib, an oral tyrosine kinase 2 (TYK2) inhibitor; and the nonsteroidal topical agents roflumilast and tapinarof will further increase the number of psoriasis treatments and make the market even more competitive.

Questions answered:

  • How do interviewed KOLs view the efficacy and safety of the IL-17 inhibitors (Cosentyx, Taltz, Siliq / Lumicef) and the emerging IL-17 A/F dual inhibitor bimekizumab, and where are/will these agents be positioned in the psoriasis treatment algorithm?
  • What will be the impact of the IL-23 inhibitors (Tremfya, Ilumya, and Skyrizi), and how will they fare in this competitive market?
  • How will the oral TYK2 inhibitor deucravacitinib affect apremilast’s (Amgen’s Otezla’s) patient share, and how will the two agents compare on efficacy and safety attributes?
  • What will be the future of the novel topical therapies roflumilast, a PDE-4 inhibitor, and tapinarof, a TAMA?

Geographies: United States, France, Germany, Italy, Spain, United Kingdom, and Japan.

Primary research: 31 country-specific interviews with thought leaders. Supported by survey data collected for this and other Clarivate research.

Epidemiology: Total diagnosed prevalence of psoriasis by country, segmented by mild and moderate to severe subpopulations.

Emerging therapies: Phase III/PR: 6 drugs; Phase II: 9 drugs; coverage of select preclinical and Phase I products.

Forecast: 10-year, annualized, drug-level sales and patient share of key psoriasis therapies through 2030, segmented by brands/generics and epidemiological subpopulations.

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