The Crohn’s disease (CD) therapy market is expected to see increasing use of biologics and grow steadily over the next decade. The well-established TNF-α inhibitors (e.g., Janssen/Merck’s Remicade, AbbVie / Eisai’s Humira), together with newer therapies (i.e., Takeda’s Entyvio, a CAM inhibitor, and Janssen’s Stelara, an IL-12/23 inhibitor), have transformed the treatment landscape for CD, especially for moderate to severe disease, despite these drugs’ efficacy limitations (e.g., patients lose response over time) and safety risks. The impending entry of several new therapies offering more-convenient formulations and/or novel mechanisms of action (e.g., Galapagos / Gilead’s filgotinib, TiGenix / Takeda’s Alofisel, AbbVie’s risankizumab and upadacitinib, Celgene’s ozanimod) will further improve treatment and intensify market competition. In balance with these trends, the continuing generic erosion of conventional agents and the availability of less-expensive biosimilar TNF-alpha inhibitors will constrain CD therapy sales.
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