The Crohn’s disease(CD) therapy market will continue to evolve over the next decade. The well-established TNF-α inhibitors (e.g., Janssen/Merck’s Remicade, AbbVie/Eisai’s Humira) helped transform the treatment landscape, especially for patients with moderate to severe disease, despite these agent’s limitations in efficacy (e.g., patients lose response over time) and safety risks. Takeda’s Entyvio, a cell adhesion molecule (CAM) inhibitor, and the introduction of the first-in-class interleukin (IL)-12/23 inhibitor, Janssen’s Stelara, have expanded physicians’ treatment armamentarium, especially for patients refractory to TNF-α inhibitors. Emerging therapies, which offer more-convenient formulations and/or havenovel mechanisms of action (e.g., Galapagos/Gilead’s filgotinib, TiGenix/Takeda’s Alofisel, AbbVie’s risankizumab), together with the increasing availability of biosimilar agents, will only intensify the competition.
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