The rising rates of antimicrobial resistance (AMR) have created an emergent need for antibiotics with activity against drug-resistant gram-negative pathogens (GNPs). Since the emergence of the COVID-19 pandemic, a potential public health threat of antibiotic-resistant bacteria is now becoming increasingly urgent. Antibiotics such as carbapenems, which have historically been reserved for later lines of therapy, are being used earlier in treatment, placing additional pressure on the already-limited GNI armamentarium. Despite the launch of novel antibiotics, such as AbbVie / Pfizer’s Avycaz / Zavicefta, Merck & Co.’s Zerbaxa and Recarbrio, and Shionogi’s Fetroja / Fetcroja, unmet need remains for additional treatment options with novel mechanisms of action and with efficacy in patients with drug-resistant infections, which are associated with high rates of mortality. Although the market is heavily genericized and cost-containment measures have limited commercial success of emerging therapies, innovative market push and pull approaches such as value-based pricing (VBP) and de-linked drug reimbursement models promise to encourage and support future antibiotics development.
Geographies: United States, France, Germany, Italy, Spain, United Kingdom, Japan
Primary research: 20 country-specific interviews with thought-leading infectious disease specialists. Supported by survey data collected for this and other Clarivate research
Epidemiology: Diagnosed cases of GNIs by country, segmented by key infections (HABP / VABP/ HCAP, CSSSI / SSI, cIAI, BSI, and UTI), pathogens (E. coli, Pseudomonas, Acinetobacter, Klebsiella), and resistance types
Forecast: 10-year, annualized, drug-level sales and patient share of key GNI therapies through 2031, segmented by brands / generics, geography, and five key infection types
Emerging therapies: Phase III/PR: 8 drugs; Phase I/Phase II: 10 drugs
Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
Disease Landscape & Forecast will feature continual updates in 2022 to provide timely insights and analyses as meaningful indication-specific news and events unfold.