Heart failure (HF) can be categorized into acute or chronic, and we focus on both settings in this report. HF patients are subject to high rates of mortality and morbidity. While much progress has been made in the pharmacological management of HF, it is mainly in chronic HF (CHF) with reduced ejection fraction (HFrEF); a significant unmet need remains for CHFwith preserved ejection fraction (HFpEF). In addition, the treatment of acute HF (AHF) is dominated by older, generic products. We provide insights into the continued uptake of Entresto over the 2017-2027 forecast period, and its expected launch for HFpEF in 2020. We also examine the potential of several new therapies for CHF (Boehringer Ingelheim/Eli Lilly’s Jardiance, AstraZeneca’s Farxiga, Lexicon Pharmaceuticals/Sanofi’s sotagliflozin, Bayer/MSD’s vericiguat, and Amgen/Cytokinetics’s omecamtiv mecarbil), and assess how the AHF market will evolve given the lack of new drug launches.