Multiple Sclerosis | Disease Landscape & Forecast | G7 | 2022

The maturing yet highly lucrative market for multiple sclerosis (MS) disease-modifying therapies (DMTs) continues to fragment as newer entrants (e.g., Novartis’s Kesimpta, Bristol Myers Squibb’s Zeposia, Biogen’s Vumerity) propel ongoing shifts and intensify competition in the saturated relapsing MS market. Meanwhile, many developers have renewed focus on developing treatments for the underserved progressive MS population, including Sanofi and Roche’s BTK inhibitors and several other novel products. Meanwhile, the U.S. launch of generics competition for Tecfidera in 2020 and the entry of more generic orals in the United States and Europe in the coming years will constrain uptake of follow-on compounds and exert new pressures on the market overall as reimbursement authorities struggle to rein in healthcare costs. Understanding these market forces will be key to the success of current and future players in this evolving market.

Questions answered:

  • What is the commercial outlook for new S1P receptor modulators and novel fumarates compared with their first-to-market counterparts? What is the market potential for new MOAs like BTK inhibitors in relapsing MS?
  • What impact has Ocrevus had in the relapsing and progressive MS markets, and how will Kesimpta and ublituximab further shape the anti-CD20s class?
  • How will the recent and anticipated launch of oral generics competition impact the MS market?
  • What do key opinion leaders think about emerging agents for progressive MS patients, and what is the commercial outlook for these therapies?

Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, Japan.

Primary research: 23 country-specific interviews with thought-leading neurologists, supported by survey data collected for this content and other Clarivate research.

Epidemiology: Diagnosed prevalence of MS by country, segmented by CIS, RR-MS, SP-MS, and PP-MS; drug-treated cases.

Emerging therapies: Phase II: 10 drugs; Phase III / preregistration: 7 drugs.

Key companies: AB Science, Banner Life Sciences, Biogen, Bristol Myers Squibb, Janssen, Merck KGaA / EMD Serono, MediciNova, Mylan, Mapi Pharma, Novartis, Roche / Genentech, Sanofi, Teva, TG Therapeutics.

Market forecast features: Patient-based market forecast extending through 2031, segmented by brands and generics / biosimilars.

Product description:

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Solution Enhancement

Disease Landscape & Forecast will feature continual updates in 2022 to provide timely insights and analyses as meaningful indication-specific news and events unfold.

Additionally, Disease Landscape & Forecast introduces a new Drug Pipeline chapter with real-time, global pipeline intelligence content directly from Cortellis. This chapter is updated daily and features interactive figures that can be easily downloaded for detailed analysis or presentations.

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