Unipolar depression’s very crowded generic therapy market makes it a challenge for branded agents to gain a strong foothold. SSRIs’ use as first-line treatments and continued position as the patient-share leaders contribute to the challenges that branded therapies face entering this market. However, the need for effective treatments that address the symptoms of the one-third of depression patients who are treatment-resistant is expected to drive growth as newer-to-market therapies (e.g., Lundbeck/Otsuka Pharmaceutical’s Rexulti/RXulti, Allergan’s Vraylar) are incorporated into the treatment paradigm and as emerging therapies targeting underserved cohorts of depression patients (e.g., Janssen’s esketamine, Allergan’s rapastinel, Alkermes’s ALKS-5461) enter the market.
Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, Japan
Primary research: Approximately 20 country-specific interviews with thought-leading psychiatrists and PCPs/GPs; supported by survey data collected for this and other DRG research.
Epidemiology: 12-month prevalence of unipolar depression by country, segmented by MDD, minor depression, and dysthymia; diagnosed and drug-treated cases of unipolar depression; 12-month prevalence of MDD by country, segmented by chronic pain status; 12-month prevalence of MDD by country, segmented by treatment-resistant status.
Emerging therapies: Phase II: 19 drugs; Phase III: 3 drugs; preregistration: 4 drugs. Coverage of 18 select preclinical and Phase I products.
Market forecast features: Patient-based market forecast extending from 2017 through 2027.
Key companies: Allergan, Alkermes, AstraZeneca, Axsome Therapeutics, Fabre-Kramer, Gedeon Richter, GlaxoSmithKline, Janssen, Lundbeck, Otsuka Pharmaceutical, Pfizer, Sage Therapeutics, Shionogi, Sumitomo Dainippon, Sunovion
Key drugs: Aripiprazole, bupropion HCl SR/XR, duloxetine, escitalopram, Latuda (lurasidone), quetiapine IR/XR, venlafaxine IR/XR, Rexulti/RXulti (brexpiprazole), Trintellix/Brintellix (vortioxetine), Vraylar (cariprazine), ALKS-5461, ASC-01, AXS-05, esketamine, gepirone ER, rapastinel, SAGE-217