Chronic Myeloid Leukemia | Current Treatment | Physician Insights | US | 2017

Chronic myeloid leukemia is a slow progressive tumor, characterized by different phases of disease (chronic, accelerated, and blast). Treatment of chronic myeloid leukemia is dominated by oral BCR-ABL tyrosine kinase inhibitors. Treatment options for newly diagnosed chronic phase disease are dominated by TKIs, including first-to-market Gleevec (Novartis), Sprycel (Bristol-Myers Squibb), and Tasigna (Novartis); treatment options for patients who are resistant or intolerant to prior therapy (and in patients with accelerated and/or blast phase disease) include Bosulif (Pfizer), Iclusig (Ariad), and Synribo (Teva).

Questions Answered:

  • What percentage of drug-treated, newly diagnosed, chronic phase chronic myeloid leukemia patients are prescribed BCR-ABL tyrosine kinase inhibitors as first-line and second-line treatment by surveyed physicians?
  • What are the key drivers and obstacles determining current prescribing patterns in the chronic myeloid leukemia treatment armamentarium?
  • How the entry of generic Gleveec has affected the treatment preference of hematologists?
  • What are surveyed physicians’ perceptions of the intended duration of tyrosine kinase inhibitor treatment for chronic myeloid leukemia versus their actual clinical practice? To what extent are their patients compliant?

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