Research Reports | Market Assessment
June 2022

Malignant Melanoma – Current Treatment – Detailed, Expanded Analysis (US)

Disease stage, primary tumor resectability, and BRAF mutation status are key parameters influencing the treatment paradigm of malignant melanoma patients. BRAF/MEK inhibitor combination regimens, such as Roche / Genentech’s Zelboraf + Cotellic ± Tecentriq, Novartis’ Tafinlar + Mekinist, and Pfizer’s Braftovi + Mektovi, are key treatment options for malignant melanoma patients harboring BRAF mutations, while immune checkpoint inhibitors, Keytruda (Merck & Co.) and Opdivo ± Yervoy (Bristol Myers Squibb), offer therapeutic options to patients regardless of mutation status. Intratumoral treatment options are limited to Amgen’s oncolytic viral therapy Imlygic, available only to patients with injectable lesions that cannot be resected. This content explores key factors driving surveyed medical oncologists’ prescribing decisions when treating malignant melanoma patients

QUESTIONS ANSWERED

  • What are the current treatment practices in the adjuvant setting and factors influencing the use of BRAF/MEK inhibitors versus anti-PD-1 therapy?
  • What is the uptake of immune checkpoint inhibitors and BRAF/MEK inhibitors for the treatment of BRAF-mutation-positive malignant melanoma patients?
  • How do drug treatment rates vary across key drug-treated patient populations, according to the stage of disease and line of therapy?
  • What drivers and constraints influence treatment decisions in the unresectable or metastatic setting for key targeted therapies?

PRODUCT DESCRIPTION

Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that marketers can create specific messaging around these treatment dynamics to more effectively increase or defend their market position.

Markets covered: United States.

Primary research: Survey of 102 U.S. medical oncologists in March 2022.

Key drugs covered: Keytruda, Opdivo ± Yervoy, Zelboraf, Cotellic, Tafinlar, Mekinist, Braftovi, Mektovi, Imlygic.

Table of contents

  • Malignant Melanoma - Current Treatment - Detailed, Expanded Analysis (US)
    • Current Treatment: Physician Insights | Malignant Melanoma | US | June 2022
Saurabh Virdi
Saurabh Virdi

Saurabh Virdi, B.Tech., is an analyst on the Oncology team at Clarivate. He has more than seven years working in the pharmaceutical industry providing analytical support in various therapy areas, including oncology, HIV, vaccines, specialty pharma, and rare diseases. Prior to joining Clarivate, he was an assistant project manager at DelveInsight Business Research LLP, where he was responsible for developing and delivering customized market and asset value forecasts. Before DelveInsight, he worked at WNS GSK Knowledge center and SmartAnalyst, where, as part of multifunctional teams, he helped clients’ decision making throughout the development journey from early-stage to marketed drugs. He obtained his bachelor’s degree in biotechnology from Delhi Technological University in India.

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