Lupus Nephritis | Current Treatment | US | 2018


SLE is an autoimmune disease that can manifest in many different organs, including the kidneys. Renal inflammation associated with SLE, also known as lupus nephritis, is among the most serious manifestations of the disease. Presently, no therapies are specifically approved for lupus nephritis. Current treatment involves drugs such as antimalarials (e.g., hydroxychloroquine), immunosuppressants (e.g., mycophenolate mofetil), biologics (e.g., Genentech/Biogen’s Rituxan), and corticosteroids. In this content, we offer valuable insights into the disease’s treatment algorithm, physician prescribing behavior, and current therapies’ patient share. A better understanding of lupus nephritis management will help pharmaceutical companies make informed decisions in this space.


  • What patient share do key drug classes and individual therapies garner in lupus nephritis?
  • Which main factors influence treatment practices in lupus nephritis? What is the sequencing of treatment for lupus nephritis? What do physicians report as recent and anticipated changes in their treatment practices?
  • Which features drive the choice of a therapy for lupus nephritis? What are the key barriers in prescribing lupus nephritis therapies?
  • What are the compliance and persistency rates for key lupus nephritis therapies?


Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that clients can create specific messaging around these treatment dynamics in order to more effectively increase or defend their market position.


United States


Survey of 50 rheumatologists and 50 nephrologists in the United States.


Mycophenolate mofetil/sodium, cyclophosphamide, azathioprine, tacrolimus, hydroxychloroquine, cyclosporine, Rituxan (rituximab), Benlysta (belimumab)


  • Factors influencing disease.
  • Management and treatment decisions.
  • Drivers of and constraints on treatment selection.
  • Physician-reported treatment.
  • Brand-level patient shares.
  • Rationale for changes in treatment approach.
  • Physician insight into persistency and compliance.
  • Physician-reported recent/anticipated changes in brand use or treatment approach.
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