The axial spondyloarthritis market is undergoing rapid change as physicians increasingly recognize both ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-AxSpA) populations. TNF-alpha inhibitors (AbbVie’s Humira, Amgen’s Enbrel, UCB’s Cimzia, and Janssen’s Simponi and Remicade) are the standard of care in AS patients who do not respond to conventional therapies such as NSAIDs. In March 2019, Cimzia became the first and only FDA-approved therapy for nr-AxSpA, and this approval may affect how physicians treat this subpopulation, which has been managed similarly to AS patients in the past. Two biosimilars of Remicade are also marketed in the United States. In 2016, Novartis’s IL-17 inhibitor Cosentyx became the first non-TNF biologic to be approved for AS and the first drug to bring a new mechanism of action to this indication in over a decade. This primary-market-research-based report explores current physician prescribing practices in both AS and nr-AxSpA patients, examining the use of biologics and conventional therapies in both indications. It also discusses factors that drive physicians’ use of key brands as well as anticipated changes in use in the coming year.
Geographies: United States.
Primary research: Survey of approximately 100 U.S. rheumatologists.
Key drugs covered: Humira, Enbrel, Cimzia, Simponi, Remicade / biosimilars, Cosentyx.
Key insights provided: Factors influencing disease management and treatment decisions; drivers and constraints of treatment selection; physician-reported treatment practices and brand-level patient shares; rationale for changes in treatment approach; physician insight on persistency and compliance; physician-reported recent / anticipated changes in brand usage or treatment approach.
Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that marketers can create specific messaging around these treatment dynamics to more effectively increase or defend their market position.